Can Tendon Autograft Function As a Meniscal Transplant

NCT06858943 | Completed

• 1 other identifier: N 207-2024
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Purpose: To evaluate the functional outcomes after using peroneus longus (PL) tendon autograft as meniscal transplantation in patients with knee joint line pain exaggerated with weight bearing following prior total or subtotal meniscectomy.

Conditions

Meniscectomy

Keywords

Meniscus ; Peroneus longus autograft

Outcome Measures

Primary Outcomes (2)

• Lysholm knee score

  functional knee score, minimum is zero, maximum value is 100, a higher score means a better outcome

  baseline, 2 years postoperative

• Knee Injury and Osteoarthritis and Outcome (KOOS) score

  osteoarthritis knee score, minimum is zero, maximum is 100, higher score means a better outcome

  baseline, and 2 years postoperative

Study Arms (1)

arthroscopic meniscus reconstruction using a tendon autograft

EXPERIMENTAL

arthroscopic meniscus reconstruction using a tendon autograft

Procedure: arthroscopic meniscus reconstruction using a tendon autograft

Interventions

arthroscopic meniscus reconstruction using a tendon autograft PROCEDURE

arthroscopic meniscus reconstruction using a tendon autograft

arthroscopic meniscus reconstruction using a tendon autograft

Eligibility Criteria

• Age: 22 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Skeletally mature patients with a history of prior subtotal or total (medial or lateral meniscus) meniscectomy.
• Post meniscectomy symptoms (medial or lateral knee joint line pain exaggerated with weight bearing).

You may not qualify if:

• Multi-ligamentous knee injuries.
• Skeletally immature patients.
• Significant osteoarthritic changes on radiographs (Ahlbäck II- V).
• Malalignment on full-length radiographs showing increased stress in the involved knee compartment.
• Presence of associated ipsilateral ankle joint problem.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty of Medicine, Cairo University

Giza, Cairo Governorate, Egypt

Location

Related Publications (4)

• Ronnblad E, Rotzius P, Eriksson K. Autologous semitendinosus tendon graft could function as a meniscal transplant. Knee Surg Sports Traumatol Arthrosc. 2022 May;30(5):1520-1526. doi: 10.1007/s00167-021-06606-8. Epub 2021 Jun 8.

  PMID: 34100999 BACKGROUND

• Kohn D. Autograft meniscus replacement: experimental and clinical results. Knee Surg Sports Traumatol Arthrosc. 1993;1(2):123-5. doi: 10.1007/BF01565466.

  PMID: 8536007 BACKGROUND

• Johnson LL, Feagin JA Jr. Autogenous tendon graft substitution for absent knee joint meniscus: a pilot study. Arthroscopy. 2000 Mar;16(2):191-6. doi: 10.1016/s0749-8063(00)90035-5.

  PMID: 10705332 BACKGROUND

• Milenin O, Strafun S, Sergienko R, Baranov K. Lateral Meniscus Replacement Using Peroneus Longus Tendon Autograft. Arthrosc Tech. 2020 Jul 22;9(8):e1163-e1169. doi: 10.1016/j.eats.2020.04.016. eCollection 2020 Aug.

  PMID: 32874897 BACKGROUND

Study Officials

• mohamed H khalil, M.D

  Cairo University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Model Details: case series of 25 patients

Study Record Dates

• First Submitted: February 28, 2025
• First Posted: March 5, 2025
• Study Start: May 1, 2022
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: March 11, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)