POCUS Screening for TAA in Hypertensive Patients in the ED

NCT06854588 | Not Yet Recruiting DMC

• 1 other identifier: NTEC-2024-753
• Study Type: observational
• Target: 1,483
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators are going to recruit hypertensive patients in the emergency department of Prince of Wales Hospital. Point-of-care ultrasound of the aorta and measurements of the aortic diameter will be obtained. Other relevant clinical data will also be obtained for analysis. The primary outcome is the number of patients with a maximum aortic diameter of ≥ 4.5 cm and/or ≥ 50% localized enlarged diameter relative to the adjacent normal segment as indicated by POCUS.

Conditions

Thoracic Aortic Aneurysm (TAA); Aortic Dissection

Outcome Measures

Primary Outcomes (1)

• number of patients with a dilated aorta

  is the number of patients with a maximum aortic diameter of ≥ 4.5 cm and/or ≥ 50% localized enlarged diameter relative to the adjacent normal segment as indicated by POCUS

  Day 1

Secondary Outcomes (1)

• number of patients with confirmed TAA

  through study completion, an average of 1 year

Other Outcomes (7)

• BMI for all participants

  at the time of recruitment

• number of CTA scans

  through study completion, an average of 1 year

• number of surgical interventions

  from recruitment to 28 days after

Study Arms (1)

hypertensive patients presenting to the emergency department

1. Adult patients aged ≥ 18 years attending the ED during the study period 2. Known history of hypertension or newly diagnosed hypertension in the ED

Diagnostic Test: Point-of-care ultrasound

Interventions

Point-of-care ultrasound DIAGNOSTIC_TEST

POCUS screening will be conducted to measure the maximum diameters at end diastole of the aortic root, ascending aorta, aortic arch, and descending thoracic aorta.

hypertensive patients presenting to the emergency department

Eligibility Criteria

• Age: 18 Years+
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

hypertensives patients attending the emergency department without known history of aortic diseases.

You may qualify if:

• Adult patients aged ≥ 18 years attending the ED during the study period
• Known history of hypertension or newly diagnosed hypertension in the ED

You may not qualify if:

• Known history of aortic aneurysm or dissection
• Previous thoracic aortic interventions or endovascular stenting
• Patients in cardiopulmonary resuscitation
• Traumatic patients
• Patients refuse to participate the study

Sponsors & Collaborators

• Chinese University of Hong Kong: lead
• Hospital Authority, Hong Kong: collaborator

Study Sites (1)

Prince of Wales Hospital

Shatin, NT, Hong Kong

Location

MeSH Terms

Conditions

Aortic Aneurysm, Thoracic; Aortic Dissection

Condition Hierarchy (Ancestors)

Aortic Aneurysm; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Aortic Diseases; Dissection, Blood Vessel; Acute Aortic Syndrome

Study Officials

• Colin A Graham, Professor

  Accident and Emergency Medicine Academic Unit, CUHK

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Colin A. Graham, Professor

CONTACT

+852 35051698; cagraham@cuhk.edu.hk

Rebecca Li, MSc

CONTACT

35051698; rebecca_1229@link.cuhk.edu.hk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 12, 2025
• First Posted: March 3, 2025
• Study Start: March 1, 2025
• Primary Completion: December 1, 2025
• Study Completion: February 1, 2026
• Last Updated: March 13, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)