Comparison of Postoperative Analgesic Efficacy of TAP Block and TFP Block in Patients Undergoing Abdominal Hysterectomy

NCT06853782 | Completed

• 1 other identifier: KA-22062
• Study Type: interventional
• Target: 77
• Locations: 1 country
• Sites: 1

Brief Summary

Total abdominal hysterectomy is one of the most commonly performed surgeries in women and is known to cause significant pain in especially early postoperative period. The goal of this clinical trial is to compare analgesic efficiacy of TAP block, which is well established by studies in hysterectomy surgeries, and TFP block, a relatively new block with good analgesic effect when used for lower abdominal surgeries, in patients undergoing abdominal hysterectomy surgery.The main parameters to compare the analgesic efficiacy of TAP and TFP blocks are;

1. 1.Pain scores in motion
2. 2.Opioid consumption

Conditions

Hysterectomy, Benign Uterine Diseases; Abdominal Pain (AP)

Keywords

Transversus Abdominis Plane Block; Transversalis Fascia Plane Block; Total Abdominal Hysterectomy; Postoperative Analgesia; Ultrasound

Outcome Measures

Primary Outcomes (1)

• Numeric Rating Scale

  Postoperative pain assessment will be performed by a researcher at 30th minutes,1st, 2nd, 12th and 24th hours after the block, using the Numerical Rating Scale (NRS) for pain in movement. Patients will be blinded to the groups they participate in and asked to rate their pain on a scale from 0 to 10, where 0 means no pain and 10 represents the worst pain they can imagine.

  Postoperative 30th minute, 1st, 2nd, 12th and 24th hours

Secondary Outcomes (6)

• Tramadol Consumption

  Postoperative 0-6th, 6-12th, 12-24th hours

• Rescue Tramadol Need

  Postoperative 0-24th hours

• Adverse Reactions

  Postoperative 24th hour

• Patient Satisfaction

  Postoperative 24th hour

• Early Mobilization

  Postoperative 24th hour

Study Arms (2)

TAP Block Group

ACTIVE COMPARATOR

In the TAP block group, the lateral transversus abdominis plane block will be performed by the anesthesiologist under ultrasound guidance using a linear probe after the completion of the surgery. Patients will receive 40 ml of 0.25% bupivacaine, administered in two equal doses, into the fascial plane between the internal oblique muscle and the transversus abdominis muscle on both sides.

Device: High Frequency Linear Probe (GE Logic e R7 Ultrasonography Device, USA)

TFP Block Group

ACTIVE COMPARATOR

In the TFP block group, the transversalis fascia plane block will be performed by the anesthesiologist under ultrasound guidance using a linear probe after the completion of the surgery. Patients will receive 40 ml of 0.25% bupivacaine, administered in two equal doses, between transversus abdominis muscle and transversalis fascia on both sides.

Device: High Frequency Linear Probe (GE Logic e R7 Ultrasonography Device, USA)

Interventions

High Frequency Linear Probe (GE Logic e R7 Ultrasonography Device, USA) DEVICE

A high frequency linear probe (GE Logic e R7 Ultrasonography Device, USA) device will be used while blocking in both groups.

TAP Block Group

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ASA scores of 1-2
• Adults aged 18+ years
• Diagnosed with benign uterine neoplasms and will undergo elective total abdominal hysterectomy via Pfannenstiel incision under general anesthesia
• Agreed to participate in the study will be included.

You may not qualify if:

• Patients with known
• Neuropathy
• Renal failure
• Hepatic failure
• Coagulopathy
• Skin infection at the site of intervention
• Allergy to local anesthetics
• BMI \> 35 kg/m²
• Hysterectomy surgery extended due to malignancy or multiple surgeries during the same hospitalization
• Emergency surgeries
• ASA scores of 3-4
• Emergency surgery
• Patients who do not consent to participate in the study will be excluded.

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University Hospital

Ankara, Turkey, 06230, Turkey (Türkiye)

Location

Related Publications (2)

• Lopez-Gonzalez JM, Lopez-Alvarez S, Jimenez Gomez BM, Arean Gonzalez I, Illodo Miramontes G, Padin Barreiro L. Ultrasound-guided transversalis fascia plane block versus anterior transversus abdominis plane block in outpatient inguinal hernia repair. Rev Esp Anestesiol Reanim. 2016 Nov;63(9):498-504. doi: 10.1016/j.redar.2016.02.005. Epub 2016 Apr 8. English, Spanish.

  PMID: 27067036 BACKGROUND

• Carney J, McDonnell JG, Ochana A, Bhinder R, Laffey JG. The transversus abdominis plane block provides effective postoperative analgesia in patients undergoing total abdominal hysterectomy. Anesth Analg. 2008 Dec;107(6):2056-60. doi: 10.1213/ane.0b013e3181871313.

  PMID: 19020158 BACKGROUND

MeSH Terms

Conditions

Abdominal Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Signs and Symptoms, Digestive

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiology and Reanimation Specialist

Study Record Dates

• First Submitted: February 24, 2025
• First Posted: March 3, 2025
• Study Start: July 15, 2023
• Primary Completion: September 12, 2023
• Study Completion: September 18, 2023
• Last Updated: January 6, 2026

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)