Effects of Rhodiola Rosea Supplementation on Mental Fatigue, Visuo-cognitive Processing, and Strength Performance

NCT06853600 | Completed

• 1 other identifier: SICEIA-2024-000283
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

This document aims to provide information to request authorization to collect data on the effects of supplementation administered 30 minutes before resistance training on the number of repetitions, execution speed, and perceived effort for the bench press and bench pull exercises. To grant authorization, an informed consent form must be signed for the use of the information. If authorization is granted, personalized information will be provided by the professional requesting the consent. It is recommended to read this document beforehand and ask any questions necessary to understand the details. If desired, the document can be taken for consultation with others, allowing ample time to make a decision. The decision is entirely voluntary. It is possible to decline authorization for the use of personal and/or health data without affecting the relationship with the professional requesting the consent or healthcare services. PURPOSE OF THIS REQUEST Participation involves attending a total of 5 sessions. The study begins with a familiarization session, which includes measurements of weight, height, and the determination of the 20-repetition maximum load (i.e., the maximum load that can be lifted between 18-22 times), which will be used in the rest of the experimental sessions. In the experimental sessions, a supplement capsule will be administered 30 minutes before starting the resistance training. The composition of the capsule will not be disclosed to ensure a triple-blind approach for participants and evaluators. The resistance training will consist of 4 supersets (each superset consisting of two exercises: bench press and bench pull). There will be 5-minute breaks between each superset and 1.5-minute breaks between the two exercises within the same superset. During the supersets, the maximum number of repetitions will be performed until reaching muscle failure. Heart rate and blood pressure will be measured during the training, and perceived effort will be recorded. No physiological samples will be collected. This study aims to provide a clearer understanding of which supplement may have the most beneficial effects when training with light loads and repetitions to failure in a superset, a topic that has not been explored before. REQUEST DETAILS The professional attending to this study is Amador García Ramos. By signing this document, authorization is given to complete questionnaires about perceived effort. POTENTIAL BENEFITS AND RISKS No specific benefits or risks are expected. Participation will contribute to increasing scientific knowledge. No compensation will be provided for authorizing the use of health data. Additionally, the researchers involved in this project will not receive specific compensation for their participation in the study.

Conditions

Sport Medicine

Keywords

Adaptogens; Fatigue; Sports supplementation; Strength training; Rhodiola Rosea; Visuo-cognitive Processing; Triple-Blinded Randomized Placebo Crossover Study

Outcome Measures

Primary Outcomes (1)

• Strength training

  The general warm-up mirrored that of the 1RM assessment. Thereafter, the specific warm-up included for each exercise 2 sets of 3 repetitions at 30% and 50% of 1RM, and a final set of 2 repetitions at 70% of 1RM. The training regimen consisted of 8 alternating sets (4 sets each) of bench press and bench pull, with a 2-minute rest period between sets, performed at 70% of the 1RM load established during the preliminary testing session. Sets were terminated when 2 consecutive repetitions were performed at a MV below 0.35 m·s-1 for the bench press and 0.60 m·s-1 for the bench pull. Participants were encouraged to perform all repetitions at maximal intent, and they received real-time MV feedback (GymAware RS; Kinetic Performance Technologies, Canberra, Australia). Strength performance was assessed by recording the number of repetitions completed (Nrep) and the velocity of the fastest repetition (MVfastest) in each set. The OMNI-Resistance Exercise Scale (OMNI-RES) of perceived exertion was

  During training

Secondary Outcomes (2)

• MOT test

  Baseline (before training) and immediately after training

• Cognitively demanding and control tasks

  Baseline (before training)

Study Arms (4)

Rhodiola Rosea and mental fatigue

EXPERIMENTAL

Dietary Supplement: Rhodiola Rosea Capsules

Rhodiola Rosea and no fatigue

EXPERIMENTAL

Dietary Supplement: Rhodiola Rosea Capsules

Placebo and mental fatigue

EXPERIMENTAL

Dietary Supplement: Rhodiola Rosea Capsules

Placebo and no fatigue

EXPERIMENTAL

Dietary Supplement: Rhodiola Rosea Capsules

Interventions

Rhodiola Rosea Capsules DIETARY_SUPPLEMENT

One of the most practical and accessible options for mitigating the occurrence of mental fatigue is the strategic use of nutritional supplements. Several nutritional supplements have been shown to reduce behavioural or subjective markers of mental fatigue, including caffeine, creatine, panax ginseng, and various vitamins or minerals. Among these, Rhodiola Rosea (RR), a supplement with purported adaptogenic and ergogenic properties, has gained attention. Several randomized controlled trials have reported reductions in mental fatigue after RR supplementation without adverse effects. The main objective of this study was to explore the effects of four days of Golden Root Extract (RR) supplementation on mental fatigue, visuo-cognitive processing, strength performance, and perceived exertion in young, healthy individuals.

Placebo and mental fatigue; Placebo and no fatigue; Rhodiola Rosea and mental fatigue; Rhodiola Rosea and no fatigue

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18 and 40 years
• At least one year of resistance training experience
• Ability to execute the bench press and bench pull exercises at maximal intentional velocity with proper technique

You may not qualify if:

• \- Any medical condition that could impede proper engagement in resistance training

Sponsors & Collaborators

• Universidad de Granada: lead

Study Sites (1)

Faculty of Sport Science

Granada, 18011, Spain

Location

Related Publications (2)

• Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003 Mar;10(2-3):95-105. doi: 10.1078/094471103321659780.

  PMID: 12725561 BACKGROUND

• Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-9. doi: 10.1016/S0944-7113(00)80078-1.

  PMID: 10839209 BACKGROUND

Related Links

• Related Info

MeSH Terms

Conditions

Fatigue

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Research Group

Study Record Dates

• First Submitted: February 20, 2025
• First Posted: March 3, 2025
• Study Start: May 25, 2024
• Primary Completion: August 30, 2024
• Study Completion: September 15, 2024
• Last Updated: March 3, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)