Retrospective Analysis of Different Quadratus Lumborum Block Techniques on Recovery Quality and Analgesic Consumption in Radical Cystectomy Patients

NCT06851520 | Completed

• 1 other identifier: 2024.297.11.04
• Study Type: observational
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective observational study evaluates the effects of different Quadratus Lumborum Block (QLB) techniques on postoperative recovery and total opioid consumption in patients undergoing radical cystectomy under general anesthesia. The study will analyze intraoperative and postoperative patient records from October 15, 2023, to October 15, 2024, at Tekirdağ Namık Kemal University Hospital. Patients who received anterior or posterior QLB for postoperative analgesia will be included. Data collection will involve demographic information, total opioid consumption (morphine milligram equivalents), recovery quality scores (QoR-15), postoperative pain scores (Visual Analog Scale, VAS), time to first rescue analgesic administration, frequency of rescue analgesic use, and incidence of postoperative nausea and vomiting (PONV). The retrospective analysis will compare the two QLB techniques to determine if there is a significant difference in postoperative opioid consumption and recovery quality. Statistical methods will be used to assess pain scores over time, opioid consumption, and overall recovery quality.

Conditions

Bladder Cancer; Postoperative Pain Management; Opioid Consumption; Recovery Quality

Outcome Measures

Primary Outcomes (1)

• Total Opioid Consumption (Morphine Milligram Equivalents) in the First 24 Hours

  The total amount of opioids (converted to morphine milligram equivalents) administered postoperatively within the first 24 hours following radical cystectomy. Continuous variable (mg of morphine equivalent)

  0-24 hours postoperatively

Secondary Outcomes (5)

• Pain Scores Using Visual Analog Scale (VAS) at Multiple Time Points

  0, 2, 6, 12, and 24 hours postoperatively

• Postoperative Recovery Quality (QoR-15 Score)

  24 hours postoperatively

• Time to First Rescue Analgesic Administration

  0-24 hours postoperatively

• Frequency of Rescue Analgesic Use

  0-24 hours postoperatively

• Incidence of Postoperative Nausea and Vomiting (PONV)

  0-24 hours postoperatively

Study Arms (2)

Anterior QLB Group

Patients who underwent radical cystectomy under general anesthesia and received anterior quadratus lumborum block (QLB) for postoperative analgesia.

Procedure: Anterior Quadratus Lumborum Block (QLB)

Posterior QLB Group

Patients who underwent radical cystectomy under general anesthesia and received posterior quadratus lumborum block (QLB) for postoperative analgesia.

Procedure: Posterior Quadratus Lumborum Block (QLB)

Interventions

Anterior Quadratus Lumborum Block (QLB) PROCEDURE

A regional anesthesia technique where local anesthetic is injected anterior to the quadratus lumborum muscle under ultrasound guidance for postoperative pain management.

Anterior QLB Group

Posterior Quadratus Lumborum Block (QLB) PROCEDURE

A regional anesthesia technique where local anesthetic is injected posterior to the quadratus lumborum muscle under ultrasound guidance for postoperative pain management.

Posterior QLB Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study includes adult patients (18-65 years old) who underwent radical cystectomy under general anesthesia at Tekirdağ Namık Kemal University Hospital between October 15, 2023, and October 15, 2024. Patients were retrospectively selected based on the administration of anterior or posterior Quadratus Lumborum Block (QLB) for postoperative analgesia. Patients with complete medical records were included, while those with missing data, coagulopathy, chronic opioid use, or unplanned open surgery conversion were excluded.

You may qualify if:

• Patients who underwent radical cystectomy under general anesthesia between October 15, 2023, and October 15, 2024.
• Patients who received anterior or posterior quadratus lumborum block (QLB) for postoperative analgesia.
• Age: 18-65 years.
• ASA Physical Status Classification: I-III.
• BMI \< 35 kg/m².
• Complete medical records available for retrospective review.

You may not qualify if:

• Patients who received a different postoperative analgesia technique (e.g., epidural, TAP block).
• Incomplete or missing medical records.
• Psychiatric disorders that could affect pain perception and reporting.
• Coagulopathy or bleeding disorders.
• Hepatic or renal failure.
• Chronic opioid use before surgery.
• Patients who required unplanned conversion to open surgery.

Sponsors & Collaborators

• Namik Kemal University: lead

Study Sites (1)

Tekirdağ Namık Kemal University Hospital

Tekirdağ, Turkey (Türkiye)

Location

Related Publications (1)

• Korgvee A, Veskimae E, Huhtala H, Koskinen H, Tammela T, Junttila E, Kalliomaki ML. Posterior quadratus lumborum block versus epidural analgesia for postoperative pain management after open radical cystectomy: A randomized clinical trial. Acta Anaesthesiol Scand. 2023 Mar;67(3):347-355. doi: 10.1111/aas.14188. Epub 2023 Jan 3.

  PMID: 36547262 BACKGROUND

MeSH Terms

Conditions

Urinary Bladder Neoplasms

Condition Hierarchy (Ancestors)

Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urinary Bladder Diseases; Urologic Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 24, 2025
• First Posted: February 28, 2025
• Study Start: October 15, 2023
• Primary Completion: October 15, 2024
• Study Completion: December 15, 2024
• Last Updated: February 28, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)