Heidelberg Registry for Hip and Knee Joint Implants and Revisions

NCT06850818 | Recruiting

• 1 other identifier: S-003/2025
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

The Endoprosthesis Registry Heidelberg (EPR-HD) is a clinical registry designed to systematically collect and analyze data from patients undergoing primary implantation or revision surgery of artificial hip and knee joints. The main objective of the registry is to evaluate long-term outcomes, complication rates, implant survival, and functional results associated with joint replacement procedures in patients with various hip and knee joint pathologies. By gathering comprehensive clinical data, EPR-HD aims to improve the understanding of patient outcomes after endoprosthetic procedures, identify potential factors influencing implant success, and support evidence-based improvements in surgical techniques and patient care. The registry includes adult patients treated at Heidelberg University Hospital, with data collected at multiple time points during routine clinical follow-up. This registry will contribute to the optimization of joint replacement strategies and promote high-quality patient care.

Conditions

Osteoarthritis; Arthroplasty

Keywords

Endoprostheses; Arthroplasty; Joint Replacement; Osteoarthritis; Registry; Knee; Hip

Outcome Measures

Primary Outcomes (1)

• Survival analysis with the endpoint revision for any reason

  Kaplan Meier Analysis

  Preoperative, 1 year, 3 years, and every 5 years

Secondary Outcomes (6)

• Knee Society Score

  preoperative, 1 year, 3 years and every 5 years

• Forgotten Joint Score

  preoperative, 1 year, 3 years and every 5 years

• Oxford Knee/Hip Score

  preoperative, 1 year, 3 years and every 5 years

• Harris Hip

  preoperative, 1 year, 3 years and every 5 years

• Tegner Activity Scale

  preoperative, 1 year, 3 years and every 5 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients undergoing surgery at the Department of Orthopedic Surgery, Heidelberg University Hospital.

You may qualify if:

• All patients undergoing hip or knee arthroplasty at our institution
• All patients undergoing revision surgery following hip oder knee arthroplasty

You may not qualify if:

• Lack of prospective consent for study participation
• Lack of capacity to provide informed consent
• Minor status (underage)

Sponsors & Collaborators

• University Hospital Heidelberg: lead

Study Sites (1)

University Hospital Heidelberg

Heidelberg, Baden-Wurttemberg, 69118, Germany

RECRUITING

MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Central Study Contacts

Mustafa Hariri, MD

CONTACT

004962215635652; mustafa.hariri@med.uni-heidelberg.de

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 20 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 22, 2025
• First Posted: February 27, 2025
• Study Start: January 1, 2007
• Primary Completion (Estimated): December 1, 2035
• Study Completion (Estimated): December 1, 2035
• Last Updated: June 11, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)