Relation Between Inflammatory Responses and Sequelae of Pediatric Corrosive Ingestion Cases in Assiut

NCT06843369 | Not Yet Recruiting

• 1 other identifier: corrosive ingestion cases
• Study Type: observational
• Target: 51
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.Evaluation of corrosive ingestion cases presented to Assiut university hospitals .
2. 2.To assess the role of leukocytic parameters and inflammatory mediators in determining the severity of pediatric corrosive injuries and their correlation with long-term outcomes.

Conditions

Corrosive Injury

Outcome Measures

Primary Outcomes (2)

• correlation between inflammatory responses and sequelae of Pediatric Corrosive Ingestion cases at Assiut University Hospitals

  Blood sample will be collected to measure Complete blood Count with differential leukocytic count in percent to assess the severity of inflammation in corrosive cases

  march 2025 to February 2026

• assess the severity of corrosive ingestion cases clinically

  through a questionnaire and DROOL corrosive ingestion score from 0 to 10 with 10 being the best score

  march 2025 to February 2026

Interventions

inflammatory markers DIAGNOSTIC_TEST

Serum amyloid A , cbc and IL-10

Eligibility Criteria

• Age: Up to 16 Years
• Sex: all
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Cases admitted to Assiut university hospitals with history of corrosive ingestion.

You may qualify if:

• All cases diagnosed with corrosive ingestion presented at Assiut university hospital.

You may not qualify if:

• Cases with pre-existing inflammatory diseases
• Cases with emergencies other than corrosive ingestion.
• Patients with delay time more than 48hours.
• Pediatric cases whose legal guardians are unavailable or refuse to provide consent.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Cheng HT, Seak CJ, Cheng CC, Chen TH, Sung CM, Kang SC, Chen YJ, Ng CJ, Lee CW, Huang SW, Huang HC, Yen TH. Profiling of inflammatory cytokines in patients with caustic gastrointestinal tract injury. PLoS One. 2021 Nov 18;16(11):e0260012. doi: 10.1371/journal.pone.0260012. eCollection 2021.

  PMID: 34793546 BACKGROUND

• Poonthottathil F, Suresh S, Nayer J, Aggarwal P. Diagnostic accuracy of drooling, reluctance, oropharynx, others, and leukocytosis score as a predictor of mortality and complications following acute corrosive ingestion. Turk J Emerg Med. 2023 Oct 3;23(4):225-231. doi: 10.4103/tjem.tjem_128_23. eCollection 2023 Oct-Dec.

  PMID: 38024188 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

blood samples

Study Officials

• hayam zakaria, prof dr

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Mariam Mohamed Gamal

CONTACT

+201007436873; mariammohamedgamal9@aun.ed.eg

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: demonstrator ( Principal Investigator)

Study Record Dates

• First Submitted: February 14, 2025
• First Posted: February 25, 2025
• Study Start: March 1, 2025
• Primary Completion: February 28, 2026
• Study Completion: March 31, 2026
• Last Updated: February 27, 2025

Record last verified: 2025-02