The Impact of Dental Health on Complications During and Following Radiotherapy in the Head and Neck Region.

NCT06840639 | Completed

• 1 other identifier: LundUH2
• Study Type: observational
• Target: 750
• Locations: 1 country
• Sites: 1

Brief Summary

Study the risk of complications after dental extractions in patients recieving radiotherapy.

Conditions

Head and Neck Neoplasms; Radiotherapy; Complications; Extracting Own Teeth

Outcome Measures

Primary Outcomes (2)

• Does dental extractions increase the risk for complications such as osteoradionecrosis?

  Type of complication when extracting teeth in conjunction with radiotherapy.

  From diagnosis of head and neck pathology, approximately 1 month before start of radiotherapy, and to the end of the medical record which may be from one year after the oncologic treatment up to 26 years after oncologic treatment.

• Does dental pathology in extracted teeth correlate with development of osteoradionecrosis?

  Are any specific dental pathology more prone to develop complications than others?

  From diagnosis of head and neck pathology, approximately 1 month before start of radiotherapy, and to the end of the medical record which may be from one year after the oncologic treatment up to 26 years after oncologic treatment.

Study Arms (2)

Dental extractions with complications

patients recieving dental extractions and developing osteoradionecrosis

Procedure: Dentoalveolar surgery

Dental extractions without complications

patients recieving dental extractions and not developing osteoradionecrosis

Interventions

Dentoalveolar surgery PROCEDURE

Surgery to extract teeth

Dental extractions with complications

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients receiving radiotherapy for malignant diagnosis (oral and oropharyngeal cancers)

You may qualify if:

• Malignant diagnosis
• radiotherapy pre or postoperative

Sponsors & Collaborators

• Lund University Hospital: lead

Study Sites (1)

Oral and Maxillofacial department

Lund, Skåne County, Sweden

Location

MeSH Terms

Conditions

Head and Neck Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms

Study Officials

• Philip Fransson, Msc

  Lund University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 8, 2024
• First Posted: February 21, 2025
• Study Start: January 1, 2024
• Primary Completion: December 1, 2024
• Study Completion: January 1, 2025
• Last Updated: February 21, 2025

Record last verified: 2024-11

Locations

SE (1)