Caries-associated Saliva Biomarkers Among Different Races

NCT06838182 | Not Yet Recruiting

• 1 other identifier: Salivary biomarkers and caries
• Study Type: observational
• Target: 22
• Locations: 0 countries
• Sites: N/A

Brief Summary

discover possible differences and develop effective preventative interventions by examining the relationship between salivary biomarkers and caries prevalence across different racial groups and Detect risk factors involved in caries incidence .

Conditions

Caries,Dental

Outcome Measures

Primary Outcomes (1)

• the patient has caries or not according to ELISA and colorimetric assay

  Change in concentration of salivary PRP( proline rich proteins) levels (ng\\ml )

  3 months

Study Arms (2)

caries free

Diagnostic Test: Salivary biomarkers tests

CARIES EXPERINCED

Diagnostic Test: Salivary biomarkers tests

Interventions

Salivary biomarkers tests DIAGNOSTIC_TEST

saliva samples are collected from participants

CARIES EXPERINCED; caries free

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

different races : Asian , African , Indian .

You may qualify if:

• Age : 19-25
• We will have 2 groups according to ICDAS classification : Not severe (ICDAS score ≤3) / Severe (ICDAS score ≥3)

You may not qualify if:

• : Those who reported daily use of alcohol or tobacco .
• Those who used antibiotics or other systemic drugs within the previous three months .
• Those who regularly used antiseptics

Sponsors & Collaborators

• Cairo University: lead

Related Publications (12)

• Abdinian M, Razavi SM, Faghihian R, Samety AA, Faghihian E. Accuracy of Digital Bitewing Radiography versus Different Views of Digital Panoramic Radiography for Detection of Proximal Caries. J Dent (Tehran). 2015 Apr;12(4):290-7.

  PMID: 26622284 BACKGROUND

• Barreto ML. Health inequalities: a global perspective. Cien Saude Colet. 2017 Jul;22(7):2097-2108. doi: 10.1590/1413-81232017227.02742017. English, Portuguese, Spanish.

  PMID: 28723991 BACKGROUND

• Beckfield J, Olafsdottir S. Health Inequalities in Global Context. Am Behav Sci. 2013;57(8):1014-1039. doi: 10.1177/0002764213487343. Epub 2013 Jun 26.

  PMID: 29104292 BACKGROUND

• Cash-Gibson L, Rojas-Gualdron DF, Pericas JM, Benach J. Inequalities in global health inequalities research: A 50-year bibliometric analysis (1966-2015). PLoS One. 2018 Jan 31;13(1):e0191901. doi: 10.1371/journal.pone.0191901. eCollection 2018.

  PMID: 29385197 BACKGROUND

• Daley S, Nugent A, Taylor GD. Dental divisions: exploring racial inequities of dental caries amongst children. Evid Based Dent. 2024 Mar;25(1):41-42. doi: 10.1038/s41432-024-00977-w. Epub 2024 Jan 26.

  PMID: 38279035 BACKGROUND

• Han C. Oral health disparities: Racial, language and nativity effects. SSM Popul Health. 2019 Jun 21;8:100436. doi: 10.1016/j.ssmph.2019.100436. eCollection 2019 Aug.

  PMID: 31372488 BACKGROUND

• Havsed K, Carda-Dieguez M, Isaksson H, Stensson M, Carlsson E, Jansson H, Malmodin D, Nord AB, Wickstrom C, Mira A. Salivary Proteins and Metabolites as Caries Biomarkers in Adolescents. Caries Res. 2024;58(6):573-588. doi: 10.1159/000540090. Epub 2024 Jul 17.

  PMID: 38972309 BACKGROUND

• Nath S, Poirier B, Ju X, Kapellas K, Haag D, Jamieson L. Periodontal disease inequities among Indigenous populations: A systematic review and meta-analysis. J Periodontal Res. 2022 Jan;57(1):11-29. doi: 10.1111/jre.12942. Epub 2021 Oct 16.

  PMID: 34655251 BACKGROUND

• Nath S, Poirier BF, Ju X, Kapellas K, Haag DG, Ribeiro Santiago PH, Jamieson LM. Dental Health Inequalities among Indigenous Populations: A Systematic Review and Meta-Analysis. Caries Res. 2021;55(4):268-287. doi: 10.1159/000516137. Epub 2021 Jun 9.

  PMID: 34107490 BACKGROUND

• Smith PD, Wright W, Hill B. Structural Racism and Oral Health Inequities of Black vs. non-Hispanic White Adults in the U.S. J Health Care Poor Underserved. 2021;32(1):50-63. doi: 10.1353/hpu.2021.0007.

  PMID: 33678680 BACKGROUND

• Stojkovic B, Igic M, Jevtovic Stoimenov T, Trickovic Janjic O, Ignjatovic A, Kostic M, Petrovic M, Stojanovic S. Can Salivary Biomarkers Be Used as Predictors of Dental Caries in Young Adolescents? Med Sci Monit. 2020 Jun 10;26:e923471. doi: 10.12659/MSM.923471.

  PMID: 32518218 BACKGROUND

• Travassos C, Williams DR. The concept and measurement of race and their relationship to public health: a review focused on Brazil and the United States. Cad Saude Publica. 2004 May-Jun;20(3):660-78. doi: 10.1590/s0102-311x2004000300003. Epub 2004 May 19.

  PMID: 15263977 BACKGROUND

MeSH Terms

Conditions

Dental Caries

Condition Hierarchy (Ancestors)

Tooth Demineralization; Tooth Diseases; Stomatognathic Diseases

Central Study Contacts

Fatma ahmed al safy, Master degree

CONTACT

00201145084182; fatomalsafy@gmai.com

shereen hafez ibrahim, phd

CONTACT

01099296591; shereen.hafez@dentistry.cu.edu.eg

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle investigator , researcher , data enterer and writing the research

Study Record Dates

• First Submitted: February 11, 2025
• First Posted: February 20, 2025
• Study Start: February 25, 2025
• Primary Completion: March 25, 2025
• Study Completion: April 25, 2025
• Last Updated: February 20, 2025

Record last verified: 2025-02