NCT06834204

Brief Summary

The purpose of this randomized clinical trial is to learn if 'complex' cancer patients who receive care guided by a health system intervention, Primary Care Connect (PC2) have their risks of cardiovascular disease (CVD) managed better than those who receive usual care. This study focuses on "complex" cancer survivors who have higher CVD risk when diagnosed with cancer because they also have had a diagnosis of 1 or more chronic conditions (e.g., hypertension, diabetes, and/or hyperlipidemia) requiring medication management. This study also aims to learn about the ease of implementing the health system intervention from the perspectives of cancer teams, primary care teams, and complex cancer patients. The main questions the study aims to answer are:

  • Do patients enrolled in the PC2 arm remain connected to their primary care teams during active cancer treatment for chronic disease management compared to patients in usual care?
  • Do patients enrolled in the PC2 arm have better management of their chronic conditions during active cancer treatment compared to patients in usual care?
  • How do the care team and patients experience this change in care delivery related to their work and care experiences? This study will compare complex cancer survivors who receive care according to the PC2 intervention to usual care to see if PC2 works to improve cardiovascular risk management. Participants will:
  • receive educational materials about the study upon enrollment
  • complete on-line or written surveys at 4 times
  • Visit the clinic for check ups and test related to the study 4 times

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
266

participants targeted

Target at P75+ for not_applicable cancer

Timeline
36mo left

Started Apr 2026

Typical duration for not_applicable cancer

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress2%
Apr 2026Apr 2029

First Submitted

Initial submission to the registry

February 4, 2025

Completed
15 days until next milestone

First Posted

Study publicly available on registry

February 19, 2025

Completed
1.2 years until next milestone

Study Start

First participant enrolled

April 15, 2026

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2028

Expected
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2029

Last Updated

March 23, 2026

Status Verified

March 1, 2026

Enrollment Period

2.2 years

First QC Date

February 4, 2025

Last Update Submit

March 20, 2026

Conditions

Keywords

primary carecancercardiovascularshared carecare coordinationimplementationcancer multi-team systemcomplex cancer survivor

Outcome Measures

Primary Outcomes (1)

  • Connected Care-Continuity with Primary Care Provider

    Three primary care visits focused on chronic disease management from time of enrollment to 18-months post-enrollment.

    From the time of enrollment to 18-months post enrollment.

Secondary Outcomes (3)

  • HEDIS quality measure of management hypertension

    Baseline, 6-months, 12-months, and 18-months

  • HEDIS quality measure of management diabetes

    Baseline, 6-months, 12-months, and 18-months

  • HEDIS quality measure of management of statin use

    Baseline, 6-months, 12-months, and 18-months

Other Outcomes (1)

  • Self-efficacy for Managing Chronic Conditions and Patient Centered Communication

    Baseline, 6-months, 12-months, and 18-months

Study Arms (2)

Usual Care

NO INTERVENTION

Patients in this arm will not receive the intervention.

Primary Care Connect (PC2)

EXPERIMENTAL

Patients enrolled in this arm will be provided print and video educational materials about the importance of shared care to manage existing and prevent exacerbations in chronic disease management. Additionally, their cancer care team will provide a brief protocolized communication to their primary care team that explain how their initial treatment may impact chronic disease management, clarifying the primary care role during acute treatment, and providing contact information for cancer team. Primary care providers of patients enrolled in this arm will receive an outreach packet that includes information provided in print and short video to explain the rationale of the intervention and the materials provided by the cancer care team.

Other: PC2: Primary Care Connect

Interventions

Primary Care Connect is a health system intervention that includes patient education, electronic medical record optimization, protocolized communication from cancer care team to primary care.

Primary Care Connect (PC2)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • diagnosed with any of the following cancers \[Stage I-III\]: breast, prostate, urinary bladder, and endometrial in the past 6 months;
  • being treated for cancer with curative intent;
  • had initial patient visit at the cancer center in the last 3 months;
  • are being treated for cancer with curative intent at the Rutgers Cancer Institute of New Jersey
  • have ≥1 CVD risk factor (hypertension, hyperlipidemia or type II diabetes) prior to cancer diagnosis that requires medication management;
  • currently receiving care from a primary care provider;
  • Speak English or Spanish

You may not qualify if:

  • had myocardial infarction or stroke within the previous 1 year;
  • have heart failure with an ejection fraction \<30%; (3) have stage IV-V chronic kidney disease (eGFR \<30);
  • or do not speak English or Spanish. Patients whose cancer progresses to metastatic disease during the course of the 18-month trial will be allowed to continue to participate unless they voluntarily withdraw

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Rutgers RWJ Medical School

Somerset, New Jersey, 08901, United States

Location

MeSH Terms

Conditions

NeoplasmsUrinary Bladder NeoplasmsProstatic NeoplasmsAdenocarcinomaEndometrial NeoplasmsHypertensionHyperlipidemiasHypercholesterolemiaDiabetes Mellitus

Condition Hierarchy (Ancestors)

Urologic NeoplasmsUrogenital NeoplasmsNeoplasms by SiteFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesUrinary Bladder DiseasesUrologic DiseasesMale Urogenital DiseasesGenital Neoplasms, MaleGenital Diseases, MaleGenital DiseasesProstatic DiseasesCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeUterine NeoplasmsGenital Neoplasms, FemaleUterine DiseasesGenital Diseases, FemaleVascular DiseasesCardiovascular DiseasesDyslipidemiasLipid Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesGlucose Metabolism DisordersEndocrine System Diseases

Study Officials

  • Dena O'Malley, PhD, MSW

    Rutgers, The State University of New Jersey

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Denalee M. O'Malley, PhD, MSW

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor Rutgers RWJ Medical School Dept Family Medicine and Community Health

Study Record Dates

First Submitted

February 4, 2025

First Posted

February 19, 2025

Study Start

April 15, 2026

Primary Completion (Estimated)

July 1, 2028

Study Completion (Estimated)

April 30, 2029

Last Updated

March 23, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

The cleaned, item-level spreadsheet data for all variables will be shared openly, along with example quantifications and transformations from initial raw data. The rationale for sharing only cleaned data is to foster ease of data reuse. The final dataset will include self-reported demographic and behavioral data from participant surveys, interviews, and medical data from lab values and chart abstractions. We will share de-identified individual-participant level (IPD) data. Appropriate measures such as deleting or masking personal identifiers (for quantitative data), and generating quasi-identifiers (e.g., participant names in qualitative interviews) will be used for data de-identification and sharing, and informed consent forms will reflect those plans. All datasets that can be shared will be deposited in Dataverse, an NIH supported data sharing resource and generalist repository, managed by Harvard university.

Shared Documents
STUDY PROTOCOL, ANALYTIC CODE
Time Frame
Shared data generated from this project will be made available as soon as possible, and no later than the time of publication or the end of the funding period, whichever comes first. The duration of preservation and sharing of the data will be a minimum of 10 years after the end of the funding period.
Access Criteria
Access/distribution/reuse of the resulting health system implementation actor scientific data (i.e., implementation planning group transcripts, interviews, nurse diaries) will be limited because even after de-identification, individuals, teams and organizations would be inferentially identifiable based on the context. Access to these data will be approved/monitored by the study PIs. Survey data and clinical trial data will be de-identified and contextual identifiers will be removed prior to sharing. All sharing will comply with local, state and federal laws and regulations, including HIPAA Privacy and Security Rules. Data will be de-identified before presentations and publications, as well as any datasets shared with qualified researchers who have obtained appropriate IRB approvals.
More information

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