Evaluation of the Expression and Prognostic Role of Tumor Stem Cell Marker SOX2 in Odontogenic Cysts and Tumors

NCT06833840 | Completed

• 1 other identifier: A06010222
• Study Type: observational
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

The pathogenesis of odontogenic lesions remains unclear; however, a probable explanation may involve the existence of tumor stem cells (TSCs), which are thought to generate both benign and malignant tumors. The preservation of stem cells during early dental development is governed by many transcription factors, including sex-determining region Y (SRY)-box 2 (SOX-2). Numerous studies observed the increased expression of SOX2 in various benign and malignant tumors, as its impact on tumorigenesis varies according to tumor type. The purpose of this study is to assess the immunoexpression of the stem cell marker SOX2 in diverse types of odontogenic cysts and tumors in order to identify its prognostic significance and to show if it correlates to clinicopathologic parameters of those odontogenic lesions.

Conditions

Odontogenic Cysts; Odontogenic Tumors

Keywords

Ameloblastoma; odontogenic keratocyst; dentigerous cyst; SOX2; immunohistochemistry

Outcome Measures

Primary Outcomes (1)

• SOX2 staining score

  Semi-quantitative method for subjectively scoring the immunohistochemical staining. Positive specimens were considered when the nucleus had brown staining.

  6 months

Study Arms (3)

Ameloblastoma group

patients diagnosed with ameloblastoma

Odontogenic keratocyst group

patients diagnosed with Odontogenic keratocyst

Dentigerous cyst group

patients diagnosed with Dentigerous cyst

Eligibility Criteria

• Gender Eligibility Details: male and female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients in the Outpatient Clinic of the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University.

You may qualify if:

• \. Patients with benign odontogenic cysts and tumors which presented either in Maxilla or Mandible ( as indicated by incisional biopsies )

You may not qualify if:

• Patients with systemic diseases that absolutely contraindicate surgical procedures.
• Malignant odontogenic tumors.

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Faculty of Dentistry, Mansoura University

Al Mansurah, Dakahlia Governorate, 12345, Egypt

Location

MeSH Terms

Conditions

Odontogenic Cysts; Odontogenic Tumors; Ameloblastoma; Dentigerous Cyst

Condition Hierarchy (Ancestors)

Jaw Cysts; Bone Cysts; Cysts; Neoplasms; Jaw Diseases; Musculoskeletal Diseases; Stomatognathic Diseases; Neoplasms by Histologic Type

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Target Duration: 12 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 21, 2025
• First Posted: February 19, 2025
• Study Start: April 1, 2022
• Primary Completion: March 30, 2023
• Study Completion: December 30, 2023
• Last Updated: February 26, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)