Preoperative Two Hours Carbohydrate Load On Pediatric Patient Undergoing Elective Surgery

NCT06833671 | Completed

• 1 other identifier: 35506/5/22
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This work evaluated the systemic effect of different preoperative carbohydrate (CHO) loads in pediatrics undergoing elective surgery.

Conditions

Preoperative; Carbohydrate; Pediatric; Elective Surgery

Outcome Measures

Primary Outcomes (1)

• C-reactive protein (CRP) level

  C-reactive protein (CRP) level was assessed two h before surgery as baseline, at induction of anesthesia, and 4 hours after the operation.

  4 hours postoperatively

Secondary Outcomes (7)

• Neutrophil/ lymphocyte ratio

  4 hours postoperatively

• Level of procalcitonin

  4 hours postoperatively

• Homeostatic model assessment for insulin resistance

  4 hours postoperatively

• Level of C-peptide

  4 hours postoperatively

• Level of random blood glucose

  Two hours before the surgery

Study Arms (3)

Apple juice group

EXPERIMENTAL

A preoperative carbohydrate load was done two hours before the operation using a10 ml/kg, with a maximal volume of 250 ml of commercial brand of apple juice (glucose 28 g in 250 ml).

Other: Apple juice

Anhydrous glucose group

EXPERIMENTAL

A preoperative carbohydrate load was done using 1.75mg/kg/dose of anhydrous glucose (Alpha Chmika).

Drug: Anhydrous glucose

Water group

OTHER

Patients received water

Other: Water

Interventions

Apple juice OTHER

A preoperative carbohydrate load was done two hours before the operation using a10 ml/kg, with a maximal volume of 250 ml of commercial brand of apple juice (glucose 28 g in 250 ml).

Apple juice group

Anhydrous glucose DRUG

A preoperative carbohydrate load was done using 1.75mg/kg/dose of anhydrous glucose (Alpha Chmika).

Anhydrous glucose group

Water OTHER

Patients received water.

Water group

Eligibility Criteria

• Age: 5 Years - 10 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Age from 5 to 10 years.
• Both sexes.
• American Society of Anesthesiologists (ASA) physical status I and II.
• Scheduled for elective surgery.

You may not qualify if:

• Diabetes mellitus.
• Insulin resistance (IR).
• Renal or hepatic insufficiency.
• Esophageal or gastric surgery or gastrointestinal disorders history (including gastroesophageal reflux, hiatal hernia, or gastritis).

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

Related Publications (1)

• Abdelwahed WMA, Abdelelsalam WM, Taha OA, Abdelbadie S, Taleb AMA. Effect of Preoperative 2-Hour Carbohydrate Load on Pediatric Patients Undergoing Elective Surgery: A Randomized Controlled Study. Anesthesiol Res Pract. 2025 Dec 3;2025:5580879. doi: 10.1155/anrp/5580879. eCollection 2025.

  PMID: 41357678 DERIVED

MeSH Terms

Interventions

Glucose; Water

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates; Hydroxides; Alkalies; Inorganic Chemicals; Anions; Ions; Electrolytes; Oxides; Oxygen Compounds

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: February 13, 2025
• First Posted: February 19, 2025
• Study Start: June 1, 2022
• Primary Completion: October 21, 2024
• Study Completion: October 21, 2024
• Last Updated: February 19, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)