Trials Sponsors Conditions Drugs Pricing

Conditions

Cancer Healthy Participants

Keywords

PegLyteMicrobiome

Outcome Measures

Primary Outcomes (1)

Percentage changes in Gut Metabolite Concentrations at 1 Month After Bowel Preparation
Study of the gut microbiota composition at 1 week after bowel preparation.
At week 1

Secondary Outcomes (1)

Percentage changes in Gut Microbiota Composition, Diversity, and Metabolite Concentrations at 1 Month and 3 Months After Bowel Preparation
At 1 month and 3 months

Study Arms (1)

Healthy volunteer participant cohort

EXPERIMENTAL

For healthy volunteer participants, PEG bowel preparation will be administered and participants will collect stool samples before and after PEG at specified timepoints.

Drug: PEGLyte bowel preparation

Interventions

PEGLyte bowel preparationDrug

Volunteers will be administered 4L of PEG bowel preparation. The following instructions will be provided with the prescription: 1. Fill the supplied container containing the bowel cleanse powder with lukewarm water (to facilitate dissolution) to the 4-liter fill line. The solution is clear and colourless when reconstituted to a final volume of 4 liters. 2. After capping the container, shake vigorously several times to ensure that the ingredients are dissolved. The solution is more palatable if chilled prior to drinking. When reconstituted use within 48 hours. 3. Attempt to drink a maximum of 4 liters at a rate of 240 mL (8 oz.) every 10 minutes, until 4 liters has been consumed or the rectal effluent is clear. Rapid drinking of each portion is preferred to drinking small amounts continuously. 4. The first bowel movements should occur approximately one hour after the start of bowel cleanse administration. Continue drinking until the watery stool is clear and free of solid matter.

Also known as: PEG

Healthy volunteer participant cohort

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 70 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Healthy volunteer participant cohort:
\> 18 years of age

Sponsors & Collaborators

Centre hospitalier de l'Université de Montréal (CHUM)
Otherlead

Study Sites (1)

Centre hospitalier de l'Université de Montréal (CHUM)

Montreal, Quebec, H2X 3E4, Canada

MeSH Terms

Conditions

Neoplasms

Study Officials

Arielle Elkrief, MD
Centre hospitalier de l'Université de Montréal (CHUM)
PRINCIPAL INVESTIGATOR

Enrollment

20 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: phase 1
Allocation: NA
Masking: NONE
Purpose: TREATMENT
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

February 13, 2025

First Posted

February 18, 2025

Study Start

December 5, 2024

Actual (reported)

Impact of PEG Bowel Preparation on Gut Microbiome Composition Recovery

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (1)

Healthy volunteer participant cohort

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (1)

Healthy volunteer participant cohort

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations