Association of Transversus Abdominis Plane Block (TAPB) with Postoperative Delirium (POD) in Elderly Patients Undergoing Major Gastrointestinal Surgery

NCT06829108 | Completed

• 1 other identifier: PLAGH-TAPB-001
• Study Type: observational
• Target: 5,220
• Locations: 0 countries
• Sites: N/A

Brief Summary

Postoperative delirium can increase postoperative adverse reactions and prognosis in elderly patients undergoing gastrointestinal surgery. This study studied the effects of ultrasound-guided transversal plane block on postoperative delirium, opioid consumption and prognosis in elderly patients undergoing gastrointestinal surgery, comprehensively evaluated the effectiveness and safety of TAPB, and evaluated its clinical value.

Conditions

Regional Anaesthesia; Postoperative Delirium (POD); Transversus Abdominis Plane Block (TAP Block)

Keywords

Regional Anaesthesia; Postoperative Delirium (POD); Transversus abdominis plane block (TAP block)

Outcome Measures

Primary Outcomes (1)

• POD incidence within 7 days postoperatively

  within 7 days postoperatively

Secondary Outcomes (3)

• intraoperative sufentanil dosage

  intraoperative

• length of hospital stay

  no more than 1 year

• mortality

  30 day after the surgery

Study Arms (1)

TAPB group and non-TAPB group

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All perioperative data required for this study were obtained from patients at the First Medical Center of the Chinese PLA General Hospital from January 2016 to March 2022.

You may qualify if:

• age ≥65 years;
• major gastrointestinal surgery, defined as procedures lasting more than one hour and involving partial resection of the stomach or intestines;
• general anesthesia with endotracheal intubation.

You may not qualify if:

• emergency surgeries;
• transanal endoscopic microsurgery (TEM);
• patients with a history of preoperative delirium, altered consciousness, or psychiatric conditions, such as epilepsy, Alzheimer's disease, Parkinson's disease, schizophrenia, and anxiety or depressive disorders, as well as encephalopathies (hepatic, pulmonary, and renal) and hydrocephalus, along with those experiencing significant preoperative visual or auditory impairments;
• patients who died within 24 h postoperatively or missing data of \>50% in their medical records.

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

Related Publications (1)

• Zhang C, Gao T, Ma HY, Wang R, Sun JJ, Ma LB, Tong L, Fu Q. Association of transversus abdominis plane block (TAPB) with postoperative delirium (POD) in elderly patients undergoing major gastrointestinal surgery: a retrospective cohort study. BMC Anesthesiol. 2025 Sep 29;25(1):464. doi: 10.1186/s12871-025-03363-w.

  PMID: 41023630 DERIVED

MeSH Terms

Conditions

Emergence Delirium

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director, Department of Anesthesiology (Cheif expert of National key research and development program of China 2018YFC2001900)

Study Record Dates

• First Submitted: February 11, 2025
• First Posted: February 17, 2025
• Study Start: January 1, 2016
• Primary Completion: March 31, 2022
• Study Completion: October 12, 2024
• Last Updated: February 17, 2025

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share