NCT06828523

Brief Summary

In this study, we will evaluate how solo, naive listeners perceive the speech of people with amyotrophic lateral sclerosis (ALS) and age-matched speakers produced across interactive and non-interactive contexts with an unfamiliar, naive interlocutor.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,300

participants targeted

Target at P75+ for not_applicable

Timeline
34mo left

Started Oct 2025

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress16%
Oct 2025Feb 2029

First Submitted

Initial submission to the registry

February 11, 2025

Completed
3 days until next milestone

First Posted

Study publicly available on registry

February 14, 2025

Completed
8 months until next milestone

Study Start

First participant enrolled

October 17, 2025

Completed
3.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 28, 2029

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 28, 2029

Last Updated

February 12, 2026

Status Verified

February 1, 2026

Enrollment Period

3.4 years

First QC Date

February 11, 2025

Last Update Submit

February 11, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Intelligibility of recorded speech

    Perceptual judgments will be provided by solo, naïve listeners who did not participate in the interactions. Listeners will hear recorded speech of PALS and age-matched speakers recorded across the different tasks and indicate what they heard. The score will be expressed in percent. The possible range is between 0-100%. The higher scores mean a better outcome.

    one 20 minute session

Study Arms (1)

Listener Perception of Speech Produced in Different Task Settings

EXPERIMENTAL

Listeners will hear recorded speech of PALS and age-matched speakers produced within interactive and non-interactive contexts and indicate what they heard.

Behavioral: Listener judgements of speech produced in different tasks

Interventions

Listeners will hear recorded speech of PALS and age-matched speakers across interactive and non-interactive tasks and indicate what they heard by clicking one of four words displayed on the screen. Standard attention checks and minimum performance thresholds (Theodore, 2021) will be used to ensure that listeners are engaged and are able to provide meaningful perceptual judgments.

Listener Perception of Speech Produced in Different Task Settings

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • passing the remote hearing screening
  • having no known speech, language or neurological disorders per self-report
  • being a native monolingual speaker of American English
  • having no experience communicating with people with dysarthria
  • being between the ages of 18 and 65.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Speech Core, Pennsylvania State University

University Park, Pennsylvania, 16802, United States

RECRUITING

Related Publications (2)

  • Olmstead, A. J., Viswanathan, N., Cowan, T., & Yang, K. (2021). Phonetic adaptation in interlocutors with mismatched language backgrounds: A case for a phonetic synergy account. Journal of Phonetics, 87, 101054. . : . .

    BACKGROUND
  • Olmstead AJ, Lee J, Viswanathan N. The Role of the Speaker, the Listener, and Their Joint Contributions During Communicative Interactions: A Tripartite View of Intelligibility in Individuals With Dysarthria. J Speech Lang Hear Res. 2020 Apr 27;63(4):1106-1114. doi: 10.1044/2020_JSLHR-19-00233. Epub 2020 Apr 17.

    PMID: 32302251BACKGROUND

MeSH Terms

Conditions

Amyotrophic Lateral Sclerosis

Condition Hierarchy (Ancestors)

Spinal Cord DiseasesCentral Nervous System DiseasesNervous System DiseasesMotor Neuron DiseaseNeurodegenerative DiseasesTDP-43 ProteinopathiesNeuromuscular DiseasesProteostasis DeficienciesMetabolic DiseasesNutritional and Metabolic Diseases

Study Officials

  • Jimin Lee, Ph.D.

    The Pennsylvania State University

    PRINCIPAL INVESTIGATOR
  • Navin Viswanathan, Ph.D.

    The Pennsylvania State University

    PRINCIPAL INVESTIGATOR
  • Anne Olmstead, Ph.D.

    The Pennsylvania State University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Anne Olmstead, Ph.D.

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Model Details: Listeners will hear recorded speech of PALS and age-matched speakers and indicate what they heard. Recorded speech consists of vowels and consonants produced in non-interactive and interactive tasks. The perceptual judgements will be compared to see whether interactive contexts have similar perceptual effects across the two groups. Plans for Assignment - This is a single group study in which all participants will engage in the same tasks.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

February 11, 2025

First Posted

February 14, 2025

Study Start

October 17, 2025

Primary Completion (Estimated)

February 28, 2029

Study Completion (Estimated)

February 28, 2029

Last Updated

February 12, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will share

The project will involve the collection of perceptual judgments and questionnaire data. All deidentified data will be shared through the Open Science Framework (osf.io). All scripts, protocols, procedures, and analyses will be shared along with the deidentified data to ensure that other researchers can verify and build on the presented results. All shared data will be made available in a format that is accessible by open-access software (e.g., R, Open Office, pdf reader). In addition, platform-specific scripts (e.g., experimental software LabVanced) will be shared with explanations so that they may be implemented across different software environments.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
Data will be shared after publication of the study.
Access Criteria
All deidentified data, metadata, and related tools will be freely available via Open Science Framework (OSF). The original audio files will be made available (for participants who consent) by request from researchers in the field to ensure responsible use.

Locations