NCT06810115

Brief Summary

Respiratory viruses are known to be a major cause of morbodity in multiple myeloma patients but prospective long-term sudies are lacking. We analysed 219 multiple myeloma patients that had 554 nasopharingeal swabs with 58 documented viral episodes. Respiratory viruses studied were rhinovirus, enterovirus, parainflienza, respirator, syncytial virus, metapneumovirus, coronavirus, bocavirus, influenza A, influenza B. Clinical data were extracted from a prospectively entered database, medical records were reviewed. We have prospectively studiend patients until May 2019 when we gathered survival data. Lastly because of Covid-19 pandemic when almost no other viral infections were isolated, we analysed clinical course of respiratory infections in patients with multiple myeloma after the pandemic.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
219

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2015

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2015

Completed
3.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2019

Completed
5.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2024

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

January 30, 2025

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 5, 2025

Completed
Last Updated

February 5, 2025

Status Verified

March 1, 2015

Enrollment Period

3.6 years

First QC Date

January 30, 2025

Last Update Submit

January 30, 2025

Conditions

Multiple MielomaRespiratory Viral Infections

Keywords

Respiratory viral infections

Outcome Measures

Primary Outcomes (1)

  • Number of respiratory viral infections in patirnts with multiple myeloma

    1 year

Study Arms (1)

Patient with multiple myeloma

Other: Viral PCR test

Interventions

Viral PCR testOTHER

Viral PCR test regardles of symptoms

Patient with multiple myeloma

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patient with multiple myeloma on observation/receiving treatment at outpatient clinuc

You may qualify if:

  • Patients with multiple myeloma

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Blimark C, Holmberg E, Mellqvist UH, Landgren O, Bjorkholm M, Hultcrantz M, Kjellander C, Turesson I, Kristinsson SY. Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients. Haematologica. 2015 Jan;100(1):107-13. doi: 10.3324/haematol.2014.107714. Epub 2014 Oct 24.

    PMID: 25344526BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Viral PCR testing

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Polona Novak, MD

Study Record Dates

First Submitted

January 30, 2025

First Posted

February 5, 2025

Study Start

October 1, 2015

Primary Completion

May 1, 2019

Study Completion

October 1, 2024

Last Updated

February 5, 2025

Record last verified: 2015-03