Examination of Lacrimal Sac and Nasal Mucosa Preparations Taken in Dacryocystorhinostomy Surgery of Patients With Nasolacrimal Duct Obstruction and Comparison of Clinical Groups With Each Other

NCT06810089 | Completed

• 1 other identifier: TTU-2023-1352
• Study Type: observational
• Target: 78
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to investigate etiology and pathogenesis of nasolacrimal duct obstruction and dacryocystitis in different adult clinic groups. The main question it aims to answer is: Are there differences in terms of staining scores between groups? There are 4 groups: Cohort 1: Primary Nasolacrimal Duct Obstruction without any dacryocystitis history Cohort 2: Primary Nasolacrimal Duct Obstruction with dacryocystitis history Cohort 3:Traumatic Nasolacrimal Duct Obstruction Cohort 4:Nasolacrimal Duct Obstruction with Membranes in the Nasolacrimal Sac

Conditions

Dacryocystitis; Dacryocystitis; Chronic; Dacryocystorhinostomy; Epiphora; Nasolacrimal Duct Obstruction; Surfactant; Mucin; Lacrimal Sac Mucosa; Nasal Mucosa

Keywords

dacryocystitis; dacryocystorhinostomy; epiphora; nasolacrimal duct obstruction; staining; mucin; surfactant; immunohistochemical

Outcome Measures

Primary Outcomes (1)

• Obtaining nasolacrimal sac and nasal mucosa staining scores

  Obtaining nasolacrimal sac and nasal mucosa staining scores is the primary outcome measure of this study. Comparison of the staining scores of hematoxylin and eosin, Periodic Acid-Schiff and various immunohistochemical markers will be made between the study groups. It will be investigated whether there is a significant difference between the groups.

  12 months

Study Arms (4)

Primary Nasolacrimal Duct Obstruction without any dacryocystitis history

Immunohistochemical staining scores of nasal mucosa nad nasolacrimal sac mucosa specimens of Primary Nasolacrimal Duct Obstruction without any dacryocystitis history who underwent external dacryocystorhinostomy surgery were compared with other groups. In this group, there were no membranes in the lacrimal sac during the surgery.

Primary Nasolacrimal Duct Obstruction with dacryocystitis history

In this group patients has had at least one dacryocystitis history. Immunohistochemical staining scores of nasal mucosa nad nasolacrimal sac mucosa specimens of Primary Nasolacrimal Duct Obstruction with dacryocystitis history who underwent external dacryocystorhinostomy surgery were compared with other groups. In this group, there were no membranes in the lacrimal sac during the surgery.

Traumatic Nasolacrimal Duct Obstruction

In this group, there were patients has traumatic nasolacrimal duct obstruction. Immunohistochemical staining scores of nasal mucosa and nasolacrimal sac mucosa specimens of Secondary Nasolacrimal Duct Obstruction who underwent external dacryocystorhinostomy surgery were compared with other groups. In this group, there were no membranes in the lacrimal sac during the surgery.

Nasolacrimal Duct Obstruction with Membranes in the Nasolacrimal Sac

In this group, dense membrane was detected in the nasolacrimal sacs during surgery. Patients with and without previous dacryocystitis who were detected to have membranes in their sacs during surgery were evaluated in this group. Immunohistochemical staining scores of nasal mucosa and nasolacrimal sac mucosa specimens of Nasolacrimal Duct Obstruction who underwent external dacryocystorhinostomy surgery were compared with other groups.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who applied to Bursa Uludağ University, School of Medicine, Department of Ophthalmology due to nasolacrimal duct obstruction and underwent external dacryocystorhinostomy surgery and had nasal mucosa and lacrimal sac mucosa samples taken were included in the study.

Sponsors & Collaborators

• Uludag University: lead

Study Sites (1)

Bursa Uludag University, School of Medicine

Bursa, 16059, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Nasal mucosa specimen and nasolacrimal sac specimen

MeSH Terms

Conditions

Dacryocystitis; Bronchiolitis Obliterans Syndrome; Lacrimal Apparatus Diseases; Lacrimal Duct Obstruction; Medullary cystic kidney disease 1

Condition Hierarchy (Ancestors)

Eye Diseases; Organizing Pneumonia; Bronchiolitis Obliterans; Bronchiolitis; Bronchitis; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Graft vs Host Disease; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 4 Weeks
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof Dr, MD

Study Record Dates

• First Submitted: January 30, 2025
• First Posted: February 5, 2025
• Study Start: May 15, 2023
• Primary Completion: February 28, 2024
• Study Completion: April 30, 2024
• Last Updated: February 5, 2025

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)