Sustained Ketamine Effectiveness for Suicidal Ideation

NCT06806475 | Completed

• 1 other identifier: 23.11.07
• Study Type: observational
• Target: 128
• Locations: 1 country
• Sites: 1

Brief Summary

As part of the usual clinical activity of the Emergency and Post-Emergency Psychiatric Department, IV ketamine is used to treat suicidal crises in depressed patients hospitalized as an add-on to the treatment of depression. This infusion can be repeated. Patients are systematically reassessed twice in the month following the last infusion, to ensure that the suicidal crisis is progressing. Psychometric assessments are part of routine care, to ensure systematic evaluation of psychopathology, intensity of depression and suicidality. Therefore existing data were re-used from the medical records of patients who had received ketamine infusions to assess the effect of ketamine on suicidal ideation and behaviour.

Conditions

Depression - Major Depressive Disorder; Suicide

Keywords

suicide; depression; major depressive disorder; ketamine

Outcome Measures

Primary Outcomes (1)

• suicidal ideation at 7 days after IV ketamine administration

  evolution of suicidal ideation at 7 days after IV ketamine administration in the context of a suicidal crisis using severity of suicidal ideation according to C-SSRS (COLUMBIA-SUICIDE SEVERITY RATING SCALE) The ideation severity subscale ranges from 1 to 5 (higher score indicating more severe ideation). The ideation intensity subscale includes 5 questions each ranging from 1 to 5 (higher score indication more intense ideation). The suicidal behavior subscale includes 4 yes/no questions. The suicidal behavior lethality subscale inquires about the level of actual or potential medical damage.

  7 days

Secondary Outcomes (8)

• suicidal ideation at 1 month after IV ketamine administration

  1 month

• Severity of depressive symptomatology at 7 days

  7 days

• Severity of depressive symptomatology at 1 month

  1 month

• suicidal ideation at 7 days after IV ketamine

  7 days

• suicidal behavior at 1 month after IV ketamine

  1 month

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients treated with IV ketamine in the Psychiatric Emergency and Post-Emergency Department (University Hospital, Montpellier) in context of suicidal crisis over the period from June 2022 to March 2024

You may qualify if:

• Patients treated with IV ketamine in the Psychiatric Emergency and Post-Emergency Department (University Hospital, Montpellier) in context of suicidal crisis
• over 18 y.o

You may not qualify if:

• Opposition to data use
• Subject deprived of liberty (by judicial or administrative decision)
• Subject protected by law (guardianship or curatorship)
• Subject not affiliated to a social security system

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

University Hospital, Montpellier

Montpellier, 34000, France

Location

Related Publications (1)

• Pastre M, Chancel R, Malestroit M, Courtet P, Olie E. Early Response to Ketamine for Suicidal Crisis Reduces Suicidal Events at 3 Months. J Clin Psychiatry. 2025 Jul 23;86(3):25m15829. doi: 10.4088/JCP.25m15829.

  PMID: 40767760 DERIVED

MeSH Terms

Conditions

Suicide; Depression; Depressive Disorder, Major

Condition Hierarchy (Ancestors)

Self-Injurious Behavior; Behavioral Symptoms; Behavior; Depressive Disorder; Mood Disorders; Mental Disorders

Study Officials

• Emilie OLIE, MD PhD

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD PhD

Study Record Dates

• First Submitted: January 28, 2025
• First Posted: February 4, 2025
• Study Start: December 1, 2023
• Primary Completion: September 23, 2024
• Study Completion: September 23, 2024
• Last Updated: March 30, 2025

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)