Comparing the Effects of Multicomponent Exercise on Cardiovascular Health and Lipid Profiles in Premenopausal and Postmenopausal Women

NCT06802484 | Completed

• 1 other identifier: 22137
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Background: The present study aimed to examine the effects of a 26-week multicomponent exercise program on lipid and lipoprotein profiles, blood pressure, and anthropometric parameters in healthy but sedentary premenopausal and postmenopausal women aged 40-60. Method: The program, comprising resistance, balance, flexibility, and aerobic exercises, aimed to identify group-specific responses and establish the program's efficacy in mitigating cardiovascular risks. Seventy-five women were recruited, and 38 completed the intervention. Participants were categorized into premenopausal (n=18), postmenopausal (n=10), and control groups (n=10). Key measures included total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides, glucose, systolic and diastolic blood pressure, and anthropometric variables. Statistical analyses employed the Shapiro-Wilk test, paired t-tests, Wilcoxon tests, and Kruskal-Wallis tests, with α=0.05.

Conditions

Menopause; Cardiovascular

Outcome Measures

Primary Outcomes (15)

• Total Cholesterol

  26-week

• Low-density lipoprotein Cholesterol

  26-week

• High-density lipoprotein Cholesterol

  26-week

• Triglycerides

  26-week

• Castelli Risk Index I

  26-week

• Castelli Risk Index II

  26-week

• Very Low-Density Lipoprotein Cholesterol

  26-week

• Glucose

  26-week

• Systolic Blood Pressure

  26-week

• Diastolic Blood Pressure

  26-week

• Heart Rate

  26-week

• Body Mass Index

  26-week

• Waist Circumference

  26-week

• Hip Circumference

  26-week

• Waist Circumference/ Hip Circumference

  26-week

Study Arms (3)

Control

NO INTERVENTION

Pre-Menopausic

EXPERIMENTAL

Other: Experimental: Pre-Menopausic

Post- Menopausic

EXPERIMENTAL

Other: Experimental: Post- Menopausic

Interventions

Experimental: Pre-Menopausic OTHER

The physical exercise program, lasting for 26 weeks, was conducted with an uninterrupted weekly frequency of 3 sessions, on non-consecutive days, in the late afternoon (at 7:30 PM), each lasting 60 minutes.

Pre-Menopausic

Experimental: Post- Menopausic OTHER

The physical exercise program, lasting for 26 weeks, was conducted with an uninterrupted weekly frequency of 3 sessions, on non-consecutive days, in the late afternoon (at 7:30 PM), each lasting 60 minutes.

Post- Menopausic

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• women aged between 40 and 60 years old;
• healthy, asymptomatic, and non-smoking;
• medical diagnosis favouring the engagement in physical-sporting activities;
• absence of clinical history related to alcoholism or uncontrolled metabolic disease;
• no clinical prescription for hypotensive pharmacological intake, cholesterol reduction, hormonal replacement therapy, or any other intervention capable of inducing alterations in lipid and lipoprotein metabolism; or
• abnormal blood sample results.

You may not qualify if:

• clinical history characterized by symptoms related to cardiovascular disease (CVD), including stroke (CVA) and coronary vascular disease (CVD), renal or hepatic disease, musculoskeletal disorders, or rheumatoid conditions that may impede full participation in the exercise program.

Sponsors & Collaborators

• University of Évora: lead

Study Sites (1)

Bruno Figueira

Evora, Portugal

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 16, 2025
• First Posted: January 31, 2025
• Study Start: May 1, 2024
• Primary Completion: August 1, 2024
• Study Completion: December 31, 2024
• Last Updated: January 31, 2025

Record last verified: 2025-01

Locations

PT (1)