Monitoring of Hydration Status in Chronic Hemodialysis Patients

NCT06798272 | Completed

• 1 other identifier: 163/20
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Background Maintaining fluid balance is one of major challenges of the dialysis therapy. It includes, in particular, the management of "dry body mass". We postulated that simple measurement of subscapular skinfold thickness before and after hemodialysis could help monitor hydration status in chronic dialysis patients. Aim of the study The aim of the study was to compare the conventional methods of monitoring hydration status during hemodialysis with an assessment of skin fold thickness. Materials and Methods 50 participants (21 F, 29 M; age 60 ±15 years) were enrolled. Directly before the hemodialysis session the following parameters were measured: body composition with bioimpedance spectroscopy, skinfold thickness in subscapular area with standardized caliper and blood tests: blood count, urea, n-terminal pro B-type natriuretic peptide (nt-proBNP) and pro-adrenomedullin (pro-ADM). The procedures were repeated at the end of three consecutive hemodialysis sessions.

Conditions

Hemodialysis; Kidney Failure; Overhydration

Keywords

hemodialysis; water-electrolyte balance; dry body mass; skinfold thickness

Outcome Measures

Primary Outcomes (1)

• changes in overhydration

  From enrollment to one week

Study Arms (1)

changes of overhydration during hemodialysis session

EXPERIMENTAL

Procedure: dialysisis with and without glucose in the dialysis

Interventions

dialysisis with and without glucose in the dialysis PROCEDURE

there were assessed three consecutive hemodialysis sessions

changes of overhydration during hemodialysis session

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• chronic hemodialysis for at least 3 months

You may not qualify if:

• severe mental disabilities, poor compliance, any acute infection, instability of the cardiovascular hemodynamic condition

Sponsors & Collaborators

• Medical University of Lodz: lead

Study Sites (1)

Central University Hospital

Lodz, 92-213, Poland

Location

MeSH Terms

Conditions

Renal Insufficiency; Water Intoxication

Interventions

Glucose

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Water-Electrolyte Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases; Poisoning; Chemically-Induced Disorders

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor MD

Study Record Dates

• First Submitted: January 16, 2025
• First Posted: January 29, 2025
• Study Start: October 10, 2021
• Primary Completion: May 10, 2023
• Study Completion: March 15, 2024
• Last Updated: January 29, 2025

Record last verified: 2025-01

Locations

PL (1)