Optical Coherence Tomography Angiography in Neurological Disease

NCT06797765 | Recruiting

• 1 other identifier: STU-2024-0876
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Optical Coherence Tomography Angiography (OCTA) is a non-invasive tool that images the neurovascular structures of the eye by using near-infrared light. Previous literature has demonstrated the potential of OCTA as a screening tool in stroke, but its utility in other neurological illness such as intracranial hemorrhage is unclear. Hence, this pilot study will gather preliminary data to support future grant applications to investigate this area more fully by recruiting patients with neurological illness and healthy controls and comparing their OCTA imaging parameters.

Conditions

Octa; Stroke; Subarachnoid Hemorrhage; Intracerebral Hemorrhage

Outcome Measures

Primary Outcomes (2)

• Vascular and Perfusion Density in healthy controls

  Quantitative measure of retinal microperfusion. No definite time points are defined since different neurological diseases have different patterns of evolution and patient/provider availability may change.

  Once (approx. 10 mins)

• Vascular and Perfusion Density in Patients with neurological disease

  Quantitative measure of retinal microperfusion. No definite time points are defined since different neurological diseases have different patterns of evolution and patient/provider availability may change.

  Throughout study completion up to 28 days

Study Arms (2)

Control

Normal healthy human subjects

Device: OCTA

Patients

Patients with neurological disease

Device: OCTA

Interventions

OCTA DEVICE

Optical Coherence Tomography Angiography

Control; Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Control and Patient population

You may qualify if:

• Age 18 years or older
• Patient admitted to the neuroscience intensive care unit with a diagnosis of: subarachnoid hemorrhage, intracerebral hemorrhage, intracranial aneurysm (ruptured or unruptured), intracranial vascular malformation, ischemic stroke, seizure disorder, intracranial infection, intracranial tumor(s), inflammatory demyelinating disease, traumatic brain injury and/or neuromuscular respiratory failure OR subjects from the community without major neurologic, cardiovascular, pulmonary or metabolic disease

You may not qualify if:

• Pregnancy
• Non-English speaking
• GCS motor score less than 6 (i.e. must be able to follow commands)
• Temporary or permanent physical limitation that renders the patient unable to sit up and look inside OCTA device

Sponsors & Collaborators

• University of Texas Southwestern Medical Center: lead

Study Sites (1)

UT Southwestern Medical Center

Dallas, Texas, 75235, United States

RECRUITING

Related Publications (1)

• Patton N, Aslam T, Macgillivray T, Pattie A, Deary IJ, Dhillon B. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat. 2005 Apr;206(4):319-48. doi: 10.1111/j.1469-7580.2005.00395.x.

  PMID: 15817102 BACKGROUND

MeSH Terms

Conditions

Stroke; Subarachnoid Hemorrhage; Cerebral Hemorrhage

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Intracranial Hemorrhages; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Noah Jouett, DO, PhD

CONTACT

214-645-7011; noah.jouett@utsouthwestern.edu

Emily Melikman, MBBS, RN

CONTACT

214-645-7011; emily.melikman@utsouthwestern.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 21, 2024
• First Posted: January 28, 2025
• Study Start: October 20, 2024
• Primary Completion (Estimated): October 20, 2026
• Study Completion (Estimated): October 20, 2026
• Last Updated: November 19, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)