Risk Factors of Paraspinal Muscles in Degenerative Lumbar Spondylolisthesis

NCT06797700 | Not Yet Recruiting

• 2 other identifiers: KHLL2025-KY0472024JSKFKT-17
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

This is a retrospectively observational study. The goal of this observational study is to analyze the risk factors of paraspinal muscles associated with the occurrence of spondylolisthesis in patients with degenerative lumbar spondylolisthesis(DLS) and to construct a predictive model. The main question it aims to answer is: Which paraspinal muscle changes are risk factors for DLS? We will collect the information of patients who have undergone lumbar MRI in our hospital and have been diagnosed with back pain ( including spondylolisthesis or no spondylolisthesis) during the period from 2022 to 2024.The collected data included gender, age, body mass index (BMI), diabetes, hypertension, occupation and imaging parameters. We will then retrospectively analyze the risk factors associated with lumbar spondylolisthesis.

Conditions

Spine Degeneration

Keywords

degenerative lumbar spondylolisthesis; paraspinal muscles; MRI

Outcome Measures

Primary Outcomes (4)

• the MF FCSA

  The functional cross-sectional areas of the multifidus muscl.Measurement it on axial T2-weighted magnetic resonance (MR) images from the L4 vertebral body levels

  Two weeks before treatment

• the ES FCSA

  The functional cross-sectional areas of the erector spinae.Measurement it on axial T2-weighted magnetic resonance (MR) images from the L4 vertebral body levels

  Two weeks before treatment

• the MF CSA

  the total cross-sectional areas of the multifidus muscl.Measurement it on axial T2-weighted magnetic resonance (MR) images from the L4 vertebral body levels

  Two weeks before treatment

• the ES CSA

  the total cross-sectional areas of the erector spinae.Measurement it on axial T2-weighted magnetic resonance (MR) images from the L4 vertebral body levels

  Two weeks before treatment

Secondary Outcomes (1)

• SMI

  Two weeks before treatment

Study Arms (2)

Group A

patients without lumbar spondylolisthesis

Group B

patients with lumbar spondylolisthesis

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who have undergone lumbar MRI in our hospital and have been diagnosed with back pain ( including spondylolisthesis or no spondylolisthesis) during the period from 2022 to 2024.

You may qualify if:

• Patients who presented to our hospital with back pain(the diagnosis was spondylolisthesis or no spondylolisthesis);
• Patients older than 50 years;
• Patients with complete clinical data and magnetic resonance imaging (MRI) before surgery.

You may not qualify if:

• The patient has previous spinal surgery;
• Patients with lumbar tumor,lumbar infection and lumbar tuberculosis;
• Patients with incomplete MRI sequence.

Sponsors & Collaborators

• The First People's Hospital of Yunnan: lead

Study Sites (1)

The First People's Hospital of Yunnan

Kunming, Yunnan, 650032, China

Location

Central Study Contacts

Xinyun Li

CONTACT

86+15750359757; 15750359757@163.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: miss

Study Record Dates

• First Submitted: January 23, 2025
• First Posted: January 28, 2025
• Study Start: March 6, 2025
• Primary Completion: April 30, 2025
• Study Completion: August 31, 2025
• Last Updated: March 5, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)