Intubation Checklist in the Intensive Care Unit

NCT06791317 | Active Not Recruiting DMC

• 1 other identifier: K2023-5312
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective study aims to explore whether the introduction of a preprocedural checklist for intubation in the intensive care unit (ICU) is associated with a lower incidence of intubation-related complications. Using a database where protocols from intubations in the ICU before implementing a checklist and after we will investigate whether a checklist affects early desaturation and hypotension after intubation.

Conditions

Critical Illness; Respiratory Failure; Unconsciousness

Outcome Measures

Primary Outcomes (2)

• Level of desaturation

  \- Peripheral oxygen saturation (SpO2) below 90% (or \>5% drop if saturation is \<90% after preoxygenation).

  From intubation up to 5 minutes after the procedure

• Level of lowering blood pressure

  A systolic arterial pressure (SAP) below 90 mmHg

  From intubation up to 5 minutes after the procedure

Secondary Outcomes (11)

• 30-day mortality

  30 days

• Ventilator days

  30 days

• Days in the intensive care unit

  3 months

• Number of intubation attempts

  1 hour

• First-pass success rate

  1 hour

Study Arms (2)

Standard care

Intubation procedure before introduction of a checklist

Other: Checklist

Checklist group

Intubation procedure after introduction of a checklist

Other: Checklist

Interventions

Checklist OTHER

A checklist for the intubation procedure was organised into the categories physiological optimisation, equipment and drugs, team line-up, and contingency plan. This checklist was implemented in the clinic.

Checklist group; Standard care

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Intensive Care Patients that undergo tracheal intubation. All patients (before and after checklist) are registered with a protocol during intubation. This protocol is registered in a Respiratory Database.

You may qualify if:

• Patient in the ICU
• Need for tracheal intubation

You may not qualify if:

• Pateint is under 18 years of age

Sponsors & Collaborators

• Karolinska University Hospital: lead

Study Sites (1)

Karolinska University Hospital, Perioperative Medicine and Intensive Care

Stockholm, 17176, Sweden

Location

Related Publications (1)

• Nejatian A, Forsberg IM, Thoro U, Sjoblom A, Kahlin J. Impact of Checklist Implementation on Endotracheal Intubation-Related Complications in Critically Ill Adults-A Retrospective Before and After Study. Acta Anaesthesiol Scand. 2025 Aug;69(7):e70103. doi: 10.1111/aas.70103.

  PMID: 40692385 DERIVED

MeSH Terms

Conditions

Critical Illness; Respiratory Insufficiency; Unconsciousness

Interventions

Checklist

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiration Disorders; Respiratory Tract Diseases; Consciousness Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Data Collection; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research group leader

Study Record Dates

• First Submitted: January 15, 2025
• First Posted: January 24, 2025
• Study Start: January 15, 2025
• Primary Completion: February 15, 2025
• Study Completion: May 15, 2025
• Last Updated: January 24, 2025

Record last verified: 2025-01

Locations

SE (1)