The Effect of Body Mass Index and Total Cholesterol Levels on Histopathological Grading in Breast Cancer Patients

NCT06786598 | Completed

• 2 other identifiers: Breast cancer gradingInstitutional review board
• Study Type: interventional
• Target: 85
• Locations: 1 country
• Sites: 1

Brief Summary

Breast cancer is a widespread cancer that affects high percentiles of women worldwide.The development and aggressiveness of breast cancer cells can be evaluated depending on the histopathological grading which reflects the degree of differentiation. Several factors related to lifestyle can impact the development of breast cancer. Obesity is an important factor that received the attention in recent years. The using of body mass index(BMI) is still the common method for identifying obesity which is defined when having 30kg/m² or more. Previous epidemiological and clinical studies found that obesity was correlated with advanced breast cancer especially in postmenopausal patients . Also, the changes in cholesterol levels can influence breast cancer risk in the context of obesity. The findings of other studies is still controversial; many studies revealed that elevated total cholesterol levels could increase breast cancer risk while others found to have no effect. Due to the possibility of previous factors' effect on breast cancer progression, we purposed in this study to assess the association of BMI and total cholesterol with histopathological grading according to menopausal status among a group of breast cancer patients in Syria

Conditions

Breast Cancer

Outcome Measures

Primary Outcomes (2)

• Evaluating The effect of body mass index and total cholesterol levels on histopathological grading in breast cancer patients

  baseline

• Assessing the body mass index between patients via dividing weight(in killogram) by height (in meter squared)

  baseline

Study Arms (1)

cholesterol titration

EXPERIMENTAL

Diagnostic Test: Cholesterol

Interventions

Cholesterol DIAGNOSTIC_TEST

Qimica/kit

cholesterol titration

Eligibility Criteria

• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• all participants after ensurement that all their clinical and demoghraphical data are completed

You may not qualify if:

• metabolic syndromes, as well as patients with statin therapy and hormonal replacement treatment.

Sponsors & Collaborators

• Tishreen University: lead

Study Sites (1)

Tishreen university

Latakia, Syria

Location

Related Publications (1)

• Llaverias G, Danilo C, Mercier I, Daumer K, Capozza F, Williams TM, Sotgia F, Lisanti MP, Frank PG. Role of cholesterol in the development and progression of breast cancer. Am J Pathol. 2011 Jan;178(1):402-12. doi: 10.1016/j.ajpath.2010.11.005. Epub 2010 Dec 23.

  PMID: 21224077 BACKGROUND

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 12, 2025
• First Posted: January 22, 2025
• Study Start: January 1, 2023
• Primary Completion: September 1, 2023
• Study Completion: October 1, 2023
• Last Updated: January 28, 2025

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

SY (1)