Dexmedetomidine and Dexamethasone Added as Adjuvant Infraclavicular Brachial Plexus Block in Upper Limb Surgery

NCT06779604 | Recruiting

• 1 other identifier: UERH-AR-ZT-11
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to investigate the effect of dexmedetomidine and dexamethasone added during USG-guided infraclavicular block on block onset time, total block time and time to first analgesic need in patients undergoing upper extremity surgery.

Conditions

Post Operative Pain; Anesthesia; Acute Pain

Keywords

infraclavicular nerve block; dexmetomidine; dexamethosone

Outcome Measures

Primary Outcomes (3)

• infraclavicular block onset time

  Sensory block / motor block onset time

  24 -48 hours

• postoperative analgesic drug requirement

  opioid total amount micrograms

  24 -48 hours

• infraclavicular total block time

  block time hours

  24 -48 hours

Secondary Outcomes (2)

• investigate the effects on VAS score and sedation level in the first 24 hours postoperatively

  24 -48 hours

• advers event Perioperative and postoperative period

  24 -48 hours

Study Arms (2)

Group Dexmedetomidine: (n:22)

A total volume of 30 mL of 0.5% bupivacaine, 14 mL of 2% lidocaine and 50 μgr of dexmedetomidine in 1 mL of normal saline is administered to the patients.

Procedure: Infraclavicular Block with Dexmedetomidine and Dexamethasone

GroupDexamethasone: (n:22)

Patients are administered 0.5% bupivacaine 15 mL, 2% lidocaine 14 mL and 4 mg dexamethasone in 1 ml normal saline with a total volume of 30 mL

Procedure: Infraclavicular Block with Dexmedetomidine and Dexamethasone

Interventions

Infraclavicular Block with Dexmedetomidine and Dexamethasone PROCEDURE

Infraclavicular block with Dexmedetomidine and Dexamethasone was performed at least 30 min before the start of the operation. The patient was positioned in a supine position arms at the sides or in 90 degree abduction, head turned to the other side. Infraclavicular block was performed with the lateral sagittal technique, while the USG probe was placed under the clavicle and medial to the coracoid process, providing a brachial plexus image in the form of a hyperechoic outer ring and hypoechoic circles, like a classic honeycomb image. A local anesthetic mixture was injected with a 100 mm block needle with negative aspiration and its spread in tissue planes was observed. If the VAS score was 3 or above, tramadol 1 mg kg-1 was administered as an analgesic drug.

Group Dexmedetomidine: (n:22); GroupDexamethasone: (n:22)

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A total of 44 adult patients 18 to 70 years, American Society of Anesthesiologists (ASA) I-II who underwent upper extremity surgery were included in Orthopedics and Traumatology Clinic.

You may qualify if:

• years
• ASA I-II

You may not qualify if:

• Under 18 years of age and older than 70 years of age,
• presence of brachial plexus injury,
• patients with bleeding diathesis,
• presence of allergy, -contralateral diaphragmatic paralysis, -
• presence of nerve injury secondary to trauma,
• pre-existing neuropathy of the surgical extremity,
• presence of severe pulmonary,
• renal and hepatic disease,
• congestive heart failure (NYHA stage 3-4),
• uncontrolled diabetes mellitus,
• history of neuromuscular disease,
• patients with extreme obesity or malnutrition (BMI \> 30 kg-1m2 or BMI \<20 kg-1m2),
• presence of epilepsy,
• history of peripheral vascular disease,
• history of chronic pain or fibromyalgia,

Sponsors & Collaborators

• Umraniye Education and Research Hospital: lead

Study Sites (1)

Umraniye Education and Research Hospital

Istanbul, Umraniye, 34034, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Pain, Postoperative; Acute Pain

Interventions

Dexmedetomidine; Dexamethasone

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Imidazoles; Azoles; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Pregnadienetriols; Pregnadienes; Pregnanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Steroids, Fluorinated

Study Officials

• ZELİHA TUNCEL, ASC PROF

  Umraniye ERH

  STUDY DIRECTOR

Central Study Contacts

ZELİHA TUNCEL, ASC PROF

CONTACT

5053577483; zelihalara@yahoo.com

ZELİHA TUNCEL, ASC PROF

CONTACT

9; zelihalara@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Anesthesia and reanimation

Study Record Dates

• First Submitted: December 22, 2024
• First Posted: January 16, 2025
• Study Start: February 1, 2026
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): July 30, 2026
• Last Updated: February 19, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)