Screening of Small Non-coding RNAs as an Auxiliary Diagnostic Biomarker for Gastric Cancer
1 other identifier
observational
300
1 country
1
Brief Summary
Gastric cancer is one of the most common malignancies of the gastrointestinal system, especially in East Asia. A host of patients are diagnosed with GC at the late stage, leading to poor patient prognosis. Therefore, there is a strong demand to develop new biomarkers to detect this tumor early. Small non-coding RNA species include microRNA (miRNA), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), tRNA-derived small RNA (tsRNA), etc. It has been demonstrated that small non-coding RNAs are involved in gastric cancer cell proliferation, metastasis, progression and survival. Hence, it is considered as an auxiliary diagnostic biomarker for gastric cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2023
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 10, 2023
CompletedFirst Submitted
Initial submission to the registry
January 10, 2025
CompletedFirst Posted
Study publicly available on registry
January 15, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
November 1, 2026
January 15, 2025
January 1, 2025
2.8 years
January 10, 2025
January 10, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Analysis of relative quantitative of small non-coding RNAs
Relative quantitative of small non-coding RNAs are detected by quantitative RT-PCR
an average of 2 years
Study Arms (2)
Gastric cancer cases from medical centers in China
Measurement of levels of circulating small non-coding RNAs
Controls from medical centers in China
Measurement of levels of circulating small non-coding RNAs
Interventions
Each participant was enrolled to assess the of relative quantitative of small non-coding RNAs
Eligibility Criteria
AFFILIATED HOSPITAL OF NANTONG UNIVERSITY
You may qualify if:
- Having signed informed consent
- Age≥ 18 years old and ≤ 85 years old
- Histologically confirmed gastric cancer
You may not qualify if:
- Other previous malignancy within 5 year
- Surgery (excluding diagnostic biopsy) within 4 weeks prior to study
- Pregnancy or lactation period
- Legal incapacity
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Affiliated Hospital of Nantong University
Nantong, Jiangsu, 226001, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Target Duration
- 1 Year
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 10, 2025
First Posted
January 15, 2025
Study Start
December 10, 2023
Primary Completion (Estimated)
October 1, 2026
Study Completion (Estimated)
November 1, 2026
Last Updated
January 15, 2025
Record last verified: 2025-01