Mortality in Brain Injury at the Intensive Care Unit (TraVi II)

NCT06776107 | Completed

• 1 other identifier: GRIVI_2024_01_TCE
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction: traumatic brain injuries are a leading cause of disability and mortality in the young population, associated mainly with traffic road accidents and violent wounds. The study aimed to analyze factors related to the mortality in patients with brain injury admitted to the intensive care unit. Methodology: Between 2019 and 2024, an analytical cross-sectional trial at Hospital Departamental de Villavicencio, Colombia was performed. Information was selected from the intensive care unit (ICU) database. Variables of interest and outcomes, such as mortality and ICU length of stay, were identified. The comparison was performed with the software Prism® for Mac iOS and Wizard® for the predictive model. Results: The study will show the factors associated with mortality of brain injury patients admitted to the intensive care unit.

Conditions

Traumatic Brain Injuries

Keywords

Brain Injuries; Traumatic Brain Injuries; Brain Concussion; Traffic Accidents; Critical Care; Colombia

Outcome Measures

Primary Outcomes (1)

• ICU mortality

  Mortality at the ICU

  30 days

Secondary Outcomes (1)

• ICU length of stay

  30 days

Study Arms (1)

Mortality

Survival

Other: Risk factor present

Interventions

Risk factor present OTHER

Demographic, and severity.

Mortality

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population was patients with traumatic brain injury who were admitted to the intensive care unit.

You may qualify if:

• Traumatic brain injury.
• Admitted to the intensive care unit.

You may not qualify if:

• Remission from another hospital.
• Decease for causes other than the brain injury.

Sponsors & Collaborators

• Hospital Departamental de Villavicencio: lead

Study Sites (1)

Hospital Departamental de Villavicencio

Villavicencio, Meta Department, 50001, Colombia

Location

Related Publications (14)

• Ortega Zufiria JM, Prieto NL, Cuba BC, Degenhardt MT, Nunez PP, Lopez Serrano MR, Lopez Raigada AB. [Mild head injury]. Surg Neurol Int. 2018 Jan 22;9(Suppl 1):S16-S28. doi: 10.4103/sni.sni_371_17. eCollection 2018. Spanish.

  PMID: 29430327 RESULT

• Gonzalez-Robledo J, Martin-Gonzalez F, Moreno-Garcia M, Sanchez-Barba M, Sanchez-Hernandez F. Prognostic factors associated with mortality in patients with severe trauma: from prehospital care to the Intensive Care Unit. Med Intensiva. 2015 Oct;39(7):412-21. doi: 10.1016/j.medin.2014.06.004. Epub 2014 Sep 2. English, Spanish.

  PMID: 25189470 RESULT

• Fonseca J, Liu X, Oliveira HP, Pereira T. Mortality prediction using medical time series on TBI patients. Comput Methods Programs Biomed. 2023 Dec;242:107806. doi: 10.1016/j.cmpb.2023.107806. Epub 2023 Sep 21.

  PMID: 37832428 RESULT

• Buh FC, Sumbele IUN, Maas AIR, Motah M, Pattisapu JV, Youm E, Meh BK, Kobeissy FH, Wang KW, Hutchinson PJA, Taiwe GS. Traumatic Brain Injury in Cameroon: A Prospective Observational Study in a Level I Trauma Centre. Medicina (Kaunas). 2023 Aug 28;59(9):1558. doi: 10.3390/medicina59091558.

  PMID: 37763678 RESULT

• Domensino AF, Tas J, Donners B, Kooyman J, van der Horst ICC, Haeren R, Aries MJH, van Heugten C. Long-Term Follow-Up of Critically Ill Patients With Traumatic Brain Injury: From Intensive Care Parameters to Patient and Caregiver-Reported Outcome. J Neurotrauma. 2024 Jan;41(1-2):123-134. doi: 10.1089/neu.2022.0474. Epub 2023 Oct 10.

  PMID: 37265152 RESULT

• Launey Y, Coquet A, Lasocki S, Dahyot-Fizelier C, Huet O, Le Pabic E, Roquilly A, Seguin P. Factors associated with an unfavourable outcome in elderly intensive care traumatic brain injury patients. a retrospective multicentre study. BMC Geriatr. 2022 Dec 30;22(1):1004. doi: 10.1186/s12877-022-03651-x.

  PMID: 36585608 RESULT

• Rowe M, Brown J, Marsh A, Thompson J. Predicting Mortality Following Traumatic Brain Injury or Subarachnoid Hemorrhage: An Analysis of the Validity of Standardized Mortality Ratios Obtained From the APACHE II and ICNARC H-2018 Models. J Neurosurg Anesthesiol. 2023 Jul 1;35(3):292-298. doi: 10.1097/ANA.0000000000000831. Epub 2022 Feb 4.

  PMID: 35125410 RESULT

• Luostarinen T, Vehvilainen J, Lindfors M, Reinikainen M, Bendel S, Laitio R, Hoppu S, Ala-Kokko T, Skrifvars M, Raj R. Trends in mortality after intensive care of patients with traumatic brain injury in Finland from 2003 to 2019: a Finnish Intensive Care Consortium study. Acta Neurochir (Wien). 2022 Jan;164(1):87-96. doi: 10.1007/s00701-021-05034-4. Epub 2021 Nov 2.

  PMID: 34725728 RESULT

• Rubiano AM, Griswold DP, Jibaja M, Rabinstein AA, Godoy DA. Management of severe traumatic brain injury in regions with limited resources. Brain Inj. 2021 Sep 19;35(11):1317-1325. doi: 10.1080/02699052.2021.1972149. Epub 2021 Sep 7.

  PMID: 34493135 RESULT

• Kokkinou M, Kyprianou TC, Kyriakides E, Constantinidou F. A population study on the epidemiology and outcome of brain injuries in intensive care. NeuroRehabilitation. 2020;47(2):143-152. doi: 10.3233/NRE-203111.

  PMID: 32741786 RESULT

• Venkatasubba Rao CP, Suarez JI, Martin RH, Bauza C, Georgiadis A, Calvillo E, Hemphill JC 3rd, Sung G, Oddo M, Taccone FS, LeRoux PD; PRINCE Study Investigators. Global Survey of Outcomes of Neurocritical Care Patients: Analysis of the PRINCE Study Part 2. Neurocrit Care. 2020 Feb;32(1):88-103. doi: 10.1007/s12028-019-00835-z.

  PMID: 31486027 RESULT

• Pappacena S, Bailey M, Cabrini L, Landoni G, Udy A, Pilcher DV, Young P, Bellomo R. Early dysglycemia and mortality in traumatic brain injury and subarachnoid hemorrhage. Minerva Anestesiol. 2019 Aug;85(8):830-839. doi: 10.23736/S0375-9393.19.13307-X. Epub 2019 Feb 7.

  PMID: 30735020 RESULT

• Volovici V, Ercole A, Citerio G, Stocchetti N, Haitsma IK, Huijben JA, Dirven CMF, van der Jagt M, Steyerberg EW, Nelson D, Cnossen MC, Maas AIR, Polinder S, Menon DK, Lingsma HF. Intensive care admission criteria for traumatic brain injury patients across Europe. J Crit Care. 2019 Feb;49:158-161. doi: 10.1016/j.jcrc.2018.11.002. Epub 2018 Nov 8.

  PMID: 30447560 RESULT

• Raj R, Bendel S, Reinikainen M, Hoppu S, Luoto T, Ala-Kokko T, Tetri S, Laitio R, Koivisto T, Rinne J, Kivisaari R, Siironen J, Skrifvars MB. Traumatic brain injury patient volume and mortality in neurosurgical intensive care units: a Finnish nationwide study. Scand J Trauma Resusc Emerg Med. 2016 Nov 8;24(1):133. doi: 10.1186/s13049-016-0320-6.

  PMID: 27821129 RESULT

MeSH Terms

Conditions

Brain Injuries, Traumatic; Brain Injuries; Brain Concussion

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Head Injuries, Closed; Wounds, Nonpenetrating

Study Officials

• Norton Perez, MD

  Hospital Departamental de Villavicencio

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ICU chief of staff

Study Record Dates

• First Submitted: December 9, 2024
• First Posted: January 15, 2025
• Study Start: January 1, 2019
• Primary Completion: November 30, 2024
• Study Completion: November 30, 2024
• Last Updated: January 15, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

CO (1)