Clinical and Laboratory Profile of Myasthenia Gravis in Children At Sohag University Hospitals

NCT06774937 | Not Yet Recruiting

• 1 other identifier: Soh-Med-24-09-03MS
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 3

Brief Summary

This study includes clinical and laboratory studies of patients with Myathenia gravis at Sohag Neurology outpatient clinic of pediatric department

Conditions

Myasthenia Gravis in Children

Outcome Measures

Primary Outcomes (1)

• Clinical and laboratory profile of patients with myasthenia gravis at Sohag Neurology Outpatient clinic of pediatric department

  All patients with myasthenia gravis in this study focusing on clinical and laboratory profile at Sohag Neurology outpatient clinic.

  Follow up for 6 months

Study Arms (1)

One group of patients againg one month to 16 years old with myasthenia gravis

Patients diagnosed with myasthenia gravis at the pediatric out patient clinic by clinical charactristics ,nerve study and laboratory data will be elligable for the study. Inclusion Criteria: * All patients from 1 month to 16 years confirmed diagnosis of myasthenia gravis by neurological and laboratory data. * Care giver accept to participate in the study.

Diagnostic Test: All patients in this study were subjected to the followings: (A) Clinical history focusing on: Sociodemographic data: age, gender , residence,and degree of consanguinity. Full neurodevelopmental his; Diagnostic Test: EMG ,rNST,Ach R antibodies & thyroid function

Interventions

All patients in this study were subjected to the followings: (A) Clinical history focusing on: Sociodemographic data: age, gender , residence,and degree of consanguinity. Full neurodevelopmental his DIAGNOSTIC_TEST

Thorough clinical examination: 1\. General examination including general look, vital signs and anthropometric measurements. 2\. Scale system include gross motor function and muscle power(Quantitative Myasthenia Gravis Scale) \[36\] 3. detailed neurological examination including motor ,sensory and reflexes. (C) Investigations: 1. Electrophysiological testing: EMG : is especially useful in diagnosis of seronegative MG and congenital myasthenic syndromes. NCS: including repetitive nerve stimulation test (r NST) 2. laboratory studies: * Serology. Detection of antibodies to the AChR supports the diagnosis of JMG. In young children where AChR antibodies are negative this can lead to difficulty in differentiating from CMS. * Thyroid function tests : 3. Imaging: • CT chest: Although thymoma in children is rare, the thymus must be imaged once JMG has been diagnosed. 4. molecular studies (when possible).

One group of patients againg one month to 16 years old with myasthenia gravis

EMG ,rNST,Ach R antibodies & thyroid function DIAGNOSTIC_TEST

C) Investigations: 1. Electrophysiological testing: EMG : is especially useful in diagnosis of seronegative MG and congenital myasthenic syndromes. NCS: including repetitive nerve stimulation test (r NST) 2. laboratory studies: * Serology. Detection of antibodies to the AChR supports the diagnosis of JMG. In young children where AChR antibodies are negative this can lead to difficulty in differentiating from CMS. * Thyroid function tests : 3. Imaging: • CT chest: Although thymoma in children is rare, the thymus must be imaged once JMG has been diagnosed. 4. molecular studies (when possible).

One group of patients againg one month to 16 years old with myasthenia gravis

Eligibility Criteria

• Age: 1 Month - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Patients: Patients diagnosed with myasthenia gravis at the pediatric out patient clinic by clinical charactristics ,nerve study and laboratory data will be elligable for the study.

You may qualify if:

• All patients from 1 month to 16 years confirmed diagnosis of myasthenia gravis by neurological and laboratory data.
• Care giver accept to participate in the study.

You may not qualify if:

• Failure to obtain informed consent. Other neurological and neuromuscular disorders. Age above 16 years.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (3)

Sohag University Hospital

Sohag, Sohag Governorate, Egypt

Location

Sohag university

Sohag, Egypt

Location

Sohag university

Sohag, Egypt

Location

MeSH Terms

Interventions

Sex

Intervention Hierarchy (Ancestors)

Reproductive Physiological Phenomena; Reproductive and Urinary Physiological Phenomena

Central Study Contacts

Menna Mohamed

CONTACT

01011707915; Mena011195@med.sohag.edu.eg

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor of pediatric in ElHelal Hospital in Sohag

Study Record Dates

• First Submitted: December 11, 2024
• First Posted: January 14, 2025
• Study Start: February 1, 2025
• Primary Completion: May 1, 2025
• Study Completion: August 1, 2025
• Last Updated: January 14, 2025

Record last verified: 2024-06

Locations

EG (3)