The Effect of Chamomile on Healing After Tooth Extraction

NCT06770166 | Completed

• 1 other identifier: 10840098-604.01.01-21824
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

After impacted wisdom tooth extraction, patients frequently complain of pain, edema, and limited mouth opening. After the procedure, patients are routinely recommended to use chlorhexidine and physiological serum-based mouthwashes. The antibacterial and anti-inflammatory effects of warm chamomile tea have been reported in the literature. In addition, the neuroprotective, antiallergic, antioxidant, antiseptic and spasmolytic properties of chamomile have been reported. The aim was to compare the effects of these gargles in terms of pain, mouth opening, burning sensation in the mouth, edema, and discoloration of the tongue and teeth.

Conditions

Tooth Extraction Status Nos

Keywords

chamomile; chlorhexidine; tooth extraction

Outcome Measures

Primary Outcomes (2)

• Patients pain value

  visual analog scale (VAS) is used for pain assessment. The patient marked the pain value on the 0-10 visual analog scale.

  The patient marked the pain value every day for one week.

• maximum mouth opening

  maximum mouth openin were measured with the reference of 11 and 41 teeth. are used for interincisal distances

  maximum mouth opening was measured preoperatively, postoperative 3rd and 7th days.

Study Arms (3)

physiological serum mouthwash group (control group)

ACTIVE COMPARATOR

After extraction, 40 patients were given saline mouthwash to use for 7 days.

Other: Physiological serum mouthwash

chlorhexidine mouthwash group

ACTIVE COMPARATOR

After extraction, 40 patients were given chlorhexidine mouthwash to use for 7 days.

Other: Chlorhexidine mouthwash

chamomile mouthwash group

ACTIVE COMPARATOR

After extraction, 40 patients were given chamomile mouthwash to use for 7 days.

Other: Chamomile mouthwash

Interventions

Physiological serum mouthwash OTHER

Physiological serum contains sodium chloride : 0.009 g/ml, sodium 154 (mEq/I), chloride 154 (mEq/I)\].

physiological serum mouthwash group (control group)

Chlorhexidine mouthwash OTHER

Chlorhexidine mouthwash contains 0.12% chlorhexidine digluconate and 0.15% benzydamine hydrochloride.

chlorhexidine mouthwash group

Chamomile mouthwash OTHER

Chamomile mouthwash contains 10% chamomile in physiological serum.

chamomile mouthwash group

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• American Society of Anesthesiologists (ASA) physical status I patients,
• did not have the medical history of being allergic to local anesthesia
• did not have the medical history of being allergic to CHX,
• did not have acute infection at the tooth area
• absence of any pathology at the area.

You may not qualify if:

• Participants with medically compromised condition,
• pregnant females
• smokers

Sponsors & Collaborators

• reyhansaglam: lead

Study Sites (1)

Istanbul Medipol University Dental School

Istanbul, Unkapani, 34083, Turkey (Türkiye)

Location

Study Officials

• reyhan saglam, PhD

  İstanbul Medipol university

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: PhD

Model Details: A prospective randomized controlled clinical trial

Study Record Dates

• First Submitted: January 6, 2025
• First Posted: January 13, 2025
• Study Start: March 1, 2019
• Primary Completion: October 26, 2024
• Study Completion: October 26, 2024
• Last Updated: January 13, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)