Impact of Chronic Cough on Activities of Daily Living and Response to Acute High-intensity Exercise

NCT06766175 | Recruiting

• 1 other identifier: 344527
• Study Type: observational
• Target: 129
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic cough is a common and debilitating condition that affects up to 10% of the global population. The health impact of chronic cough is multifaceted and manifests both physical and psychological symptoms including syncope, chest pain, lethargy, depression and anxiety. It is now also recognised that chronic cough often leads to social isolation and may impact an individual's ability or confidence to undertake routine daily tasks / lead an active lifestyle. The primary aim of this study is therefore to characterise the impact of unexplained chronic cough on the ability to undertake daily activities - i.e., determine whether individuals with chronic cough exhibit impaired levels of physical activity during usual daily living when compared with healthy age, gender and BMI matched controls. A secondary aim is to assess the short-term impact of high-intensity exercise on cough (i.e., determine whether an acute bout of exercise alters cough frequency and/or severity).

Conditions

Chronic Cough (CC)

Keywords

Cough; Physical activity; Exercise; Physiology

Outcome Measures

Primary Outcomes (1)

• Physical activity status assessed using objective wearable accelerometer (ActiGraph LEAP)

  Physical activity status including: \- Absolute daily steps

  1-week

Study Arms (1)

Chronic cough as per European Respiratory Society definition (>8 weeks duration)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with unexplained chronic cough will be recruited from the Hull Cough Clinic, Castle Hill Hospital.

You may qualify if:

• Age \>18 years
• Chronic cough as per European Respiratory Society definition (\>8 weeks duration)
• High symptom burden (i.e., cough visual analogue scale \>40 mm at pre-study screening)
• Chest radiograph or CT within 3 years of the screening visit with no abnormalities considered to contribute to chronic cough

You may not qualify if:

• Smokers or individuals who gave up smoking within 12 months
• Smoking history \>20 pack-years
• Long-COVID or post-COVID syndrome (defined as symptoms lasting over 12-weeks in duration)
• Currently taking any of the following medications:
• Medical history of asthma or exercise-induced bronchoconstriction (EIB), COPD, or chronic bronchitis in the judgement of the investigator
• Medical conditions/history or other circumstances which, in the judgement of the investigators, could increase the risk of adverse events or bias the study results

Sponsors & Collaborators

• University of Leeds: lead
• Hull York Medical School: collaborator
• King's College Hospital NHS Trust: collaborator
• Royal Brompton & Harefield NHS Foundation Trust: collaborator

Study Sites (1)

University of Leeds

Leeds, West Yorkshire, LS2 9JT, United Kingdom

RECRUITING

MeSH Terms

Conditions

Chronic Cough; Cough; Motor Activity

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Central Study Contacts

Oliver J Price, PhD

CONTACT

+44(0)113 343 2909; o.price1@leeds.ac.uk

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 13, 2024
• First Posted: January 9, 2025
• Study Start: December 1, 2024
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: January 9, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)