Integrating Cognitive Assessments Into the Heat Tolerance Test After Exertional Heat Injury

NCT06764264 | Completed DMC

• 1 other identifier: IDF- 123 1779-2017
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study is to evaluate soldiers post-exertional heat injury (EHI) during a heat tolerant test (HTT) to investigate the impact on their cognitive performance.

Conditions

Exertional Heat Injury

Keywords

Heat Tolerance Test; Exertional heat injury; Cognitive Impairment; Thermoregulatory Function

Outcome Measures

Primary Outcomes (1)

• Number of Participants Classified as Heat-Intolerant during Heat Tolerant Test

  Participants are classified as heat-intolerant if they exhibit any of the following indicators during the Heat Tolerance Test: a core body temperature (Tre) ≥ 38.5°C (≥ 101.38°F), a heart rate (HR) ≥ 150 bpm, or failure to achieve a Tre-to-HR ratio ≥ 0.2798°C ∙ bpm-¹. Participants meeting none of these criteria are classified as heat-tolerant.

  120 minutes

Study Arms (1)

Combat soldiers post exertional heat injury

Participants were classified into heat-intolerant (HI) or heat-tolerant (HT) groups based on their HTT physiological outcomes.

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Israeli Defense Forces combat soldiers

You may qualify if:

• Combat soldiers post exertional heat injury

You may not qualify if:

• Additional medical condition restricting combat duty

Sponsors & Collaborators

• Medical Corps, Israel Defense Force: lead
• The Chaim Sheba Medical Center: collaborator

Study Sites (1)

Heller Institute, Institute of Military Physiology, IDF Medical Corps

Tel Litwinsky, Israel, Israel

Location

Related Publications (4)

• Moran DS, Shitzer A, Pandolf KB. A physiological strain index to evaluate heat stress. Am J Physiol. 1998 Jul;275(1):R129-34. doi: 10.1152/ajpregu.1998.275.1.R129.

  PMID: 9688970 BACKGROUND

• Epstein Y, Sohar E, Shapiro Y. Exertional heatstroke: a preventable condition. Isr J Med Sci. 1995 Jul;31(7):454-62.

  PMID: 7607879 BACKGROUND

• Moran DS, Heled Y, Still L, Laor A, Shapiro Y. Assessment of heat tolerance for post exertional heat stroke individuals. Med Sci Monit. 2004 Jun;10(6):CR252-7. Epub 2004 Jun 1.

  PMID: 15173669 BACKGROUND

• Moran DS, Erlich T, Epstein Y. The heat tolerance test: an efficient screening tool for evaluating susceptibility to heat. J Sport Rehabil. 2007 Aug;16(3):215-21. doi: 10.1123/jsr.16.3.215.

  PMID: 17923727 BACKGROUND

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Daniel S Moran, PhD

  Institute of Military Physiology, IDF Medical Corps, Tel Hashomer, Israel

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. Sagi Shpitzer, MD, Chief Medical Officer, IDF Physiology Institute, Principal Investigator

Study Record Dates

• First Submitted: December 24, 2024
• First Posted: January 8, 2025
• Study Start: February 1, 2018
• Primary Completion: December 21, 2024
• Study Completion: December 21, 2024
• Last Updated: January 8, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: The data are available, and sharing will be considered if the corresponding author receives a reasonable request and establishes an institution-to-institution data-sharing agreement.
• Access Criteria: Sharing will be considered if the corresponding author receives a reasonable request and establishes an institution-to-institution data-sharing agreement.

Locations

IL (1)