Skeletal Muscle Mass Used to Assess Frailty in Older Gastric Cancer Patients

NCT06763068 | Completed

• 1 other identifier: 2020-273-2
• Study Type: observational
• Target: 575
• Locations: 1 country
• Sites: 1

Brief Summary

The primary aim of this study was to quantify the diagnosis of pre-surgical skeletal muscle mass in elderly gastric cancer patients and to analyse its correlation with frailty. The second aim was to investigate whether skeletal muscle mass, or sarcopenia, is associated with mobility and nutritional status, and anxiety and depression. The main questions it aims to answer are whether skeletal muscle mass is significantly associated with frailty and whether it can be used as a brief screening tool for preoperative frailty.

Conditions

Gastric (Stomach) Cancer; Frailty; Sarcopenia; Malnutrition Elderly

Keywords

gastric cancer; skeletal muscle mass; frailty; sarcopenia

Outcome Measures

Primary Outcomes (2)

• Skeletal muscle mass

  Skeletal muscle mass was measured by bioelectrical impedance analysis(BIA) and was classified as sarcopenia if it was less than 7.0 kg/m2 in men and 5.7 kg/m2 in women.

  Within 24 hours of admission

• frailty

  The Tilburg frailty scale was used to assess the frailty of older people with gastric cancer. The Tilburg frailty scale was compiled by Gobbens et al. The scale contains 15 items in three dimensions of physical, psychological and social frailty. The total score of the scale is 0-15 points and the cut-off value of the total scale was 5, with higher score indicating more severe frailty.

  Within 24 hours of admission and discharge

Secondary Outcomes (2)

• Nutritional Status

  Within 24 hours of admission and discharge

• anxiety and depression

  Within 24 hours of admission and discharge

Interventions

Skeletal muscle mass and frailty OTHER

Measurement correlation variable

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Convenience sampling method was used to select older people with gastric cancer who attended a tertiary care hospital in China from March 2021 to December 2022 as the study objects

You may qualify if:

• diagnosed with gastric cancer by endoscopy or pathology; age \>60 years old; radical gastrectomy was proposed; be able to communicate simply in writing and verbal.

You may not qualify if:

• received preoperative radiotherapy or chemotherapy; combined with other sites of malignant tumors; combined with severe heart, liver, lung and renal insufficiency; recent using hormones, immunosuppressants; with physical disabilities.

Sponsors & Collaborators

• Nanjing Medical University: lead

Study Sites (1)

Nanjing Medical University

Nanjing, Jiangsu, 211166, China

Location

MeSH Terms

Conditions

Stomach Neoplasms; Frailty; Sarcopenia

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD student

Study Record Dates

• First Submitted: January 2, 2025
• First Posted: January 8, 2025
• Study Start: March 1, 2021
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: January 8, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)