Analysis of Biological Progression and Regression of HELLP Syndrome in Time

NCT06758960 | Completed

• 1 other identifier: 67/2024
• Study Type: observational
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

Prospective observational study about progression and regression of biological parameters of HELLP syndrome

Conditions

HELLP Syndrome; Preeclampsia

Keywords

Preeclampsia; HELLP syndrome; Thrombocytopenia; Maternal mortality

Outcome Measures

Primary Outcomes (1)

• Platelets count

  Platelets count will be monitored daily before and after delivery

  Up to 10 days

Secondary Outcomes (2)

• Concentration of Lactate dehydrogenase

  Up to 10 days

• Concentration of Liver enzymes

  Up to 10 days

Eligibility Criteria

• Gender Eligibility Details: FEMALE
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant patients admitted to the maternal ICU from the Obstetrics Emergency department of marrakesh

You may qualify if:

• Pregnant women who are admitted to the maternal ICU for a biological HELLP syndrome

You may not qualify if:

• Patients whose biological presentation was attributable to other conditions, such as microangiopathies or leukemia.
• Patients who benefited from plasma exchange therapy

Sponsors & Collaborators

• CHU Mohammed VI Marrakech: lead

Study Sites (1)

CHU Mohammed VI of Marrakech

Marrakesh, Marrakech - Safi, 40000, Morocco

Location

Related Publications (2)

• Martin JN Jr, Blake PG, Lowry SL, Perry KG Jr, Files JC, Morrison JC. Pregnancy complicated by preeclampsia-eclampsia with the syndrome of hemolysis, elevated liver enzymes, and low platelet count: how rapid is postpartum recovery? Obstet Gynecol. 1990 Nov;76(5 Pt 1):737-41. doi: 10.1097/00006250-199011000-00001.

  PMID: 2216215 BACKGROUND

• Martin JN Jr, Blake PG, Perry KG Jr, McCaul JF, Hess LW, Martin RW. The natural history of HELLP syndrome: patterns of disease progression and regression. Am J Obstet Gynecol. 1991 Jun;164(6 Pt 1):1500-9; discussion 1509-13. doi: 10.1016/0002-9378(91)91429-z.

  PMID: 2048596 BACKGROUND

MeSH Terms

Conditions

HELLP Syndrome; Pre-Eclampsia; Thrombocytopenia; Maternal Death

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Blood Platelet Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Cytopenia; Parental Death; Death; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Meryem Essafti, Assistant Professor

  CHU Mohammed VI Marrakech

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 14 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 15, 2024
• First Posted: January 6, 2025
• Study Start: July 1, 2023
• Primary Completion: July 31, 2025
• Study Completion: August 31, 2025
• Last Updated: March 31, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR
• Time Frame: Beginning 3 months and ending 1 year after the publication of results

Locations

MO (1)