Association Between Uric Acid / High Density Lipoprotein Ratio and Monocyte / High Density Lipoprotein Ratio with Diabetic Complications

NCT06754813 | Not Yet Recruiting

• 1 other identifier: HDL Uric UHR monocyte MHR DM
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

Type 2 diabetes mellitus (T2DM) poses a formidable global health challenge, with complications arising in both the microvascular and macrovascular domains as glycemic control worsens.the aim of the study to evaluate uric acid / high density lipoprotein cholesterol ratio and monocyte / high density lipoprotein ratio in studied groups. Association between Uric Acid / high density lipoprotein cholesterol ratio and monocyte / high density lipoprotein cholesterol ratio and diabetic Complications (macrovascular and microvascular).

Conditions

Diabetes Mellitus

Outcome Measures

Primary Outcomes (2)

• uric acid / high density lipoprotein cholesterol ratio

  Calculation of UHR was calculated by dividing serum uric acid value by HDL-c value

  baseline

• monocyte / high density lipoprotein ratio

  calculated by dividing of count of monocyte by HDL-c level

  baseline

Study Arms (3)

group 1

Diabetic patients without any macrovascular and microvascular Complications.

group 2

Diabetic patients with macrovascular (stroke, coronary heart disease, Peripheral artery disease) and microvascular (DN and DR) complications

group 3

Apparent healthy subjects as control group.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

diabetic patients who attending the Diabetes Clinic of Internal Medicine Department, Assiut University Hospital from January 2025 till January 2026.

You may qualify if:

• type 2 diabetic patients
• age more than 18 years old
• both sex

You may not qualify if:

• Individuals with malignancies, pregnant women, those using furosemide, thiazide, acetylsalicylic acid, losartan group drugs, cholesterol lowering drugs, patients with other autoimmune disorders, patients with chronic kidney disease and gout.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (1)

• American Diabetes Association Professional Practice Committee. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2024. Diabetes Care. 2024 Jan 1;47(Suppl 1):S20-S42. doi: 10.2337/dc24-S002.

  PMID: 38078589 BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Central Study Contacts

Mennat Allah Gamal Abdelnaser, resident doctor

CONTACT

+201157429995; menaagamal23@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor at Assiut University hospital

Study Record Dates

• First Submitted: December 24, 2024
• First Posted: January 1, 2025
• Study Start: January 1, 2025
• Primary Completion: January 1, 2026
• Study Completion: March 1, 2026
• Last Updated: January 1, 2025

Record last verified: 2024-12