Oral Health and Endometriosis: A Cohort Study

NCT06753162 | Completed

• 1 other identifier: endometriosis-oralhealt
• Study Type: observational
• Target: 4,079
• Locations: 1 country
• Sites: 1

Brief Summary

A survey has been conducted thanks to a questionnaire composed of 45 questions. The study group was composed of 4079 women affected by endometriosis, recruited from dedicated communities present on the social network Facebook. The questionnaire investigated about: the endometriosis status, the kind of therapy, the presence of any sign and symptoms in the oral cavity, the presence of periodontal problems, the self-perception of the oral health status, the presence of other autoimmune diseases and oral hygiene and the eating habits, physical activity practiced, the life quality.

Conditions

Endometriosis

Keywords

endometriosis; Oral Health; Periodontitis; Gengivitis

Outcome Measures

Primary Outcomes (3)

• Response Patterns Based on Multiple Correspondence Analysis Dimensions

  To evaluate the possible correlations between endometriosis and the perception of periodontal disease, a score was created to summarize on a numerical scale the responses to survey questions describing the perception of oral cavity disorders. Multiple Correspondence Analysis (MCA) was used to explore relationships between responses. For the MCA, only questions with a p-value \< 0.25 in the univariate analysis were included. The responses to the questions were labeled as "yes," "no," and "I don't know". In the case of question Q11, a grade was assigned to the responses as follows: "Idk" (I don't know), "Grd0" (Insufficient), "Grd1" (Average), "Grd2" (Good), "Grd3" (Very Good), and "Grd4" (Perfect).

  1 year

• Epidemiological Analysis

  It was statistically evaluated whether the severity of endometriosis increased significantly with age.

  1 year

• Comparative Analysis of Oral Cavity Disorders Across Different Stages of Endometriosis

  The correlation between general gum bleeding and the stage of the disease was statistically evaluated.

  1 year

Eligibility Criteria

• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Women suffering from endometriosis

You may not qualify if:

• Pregnancy.
• Administration of antibiotics in the last 15 days prior to entry into the study or indications for antibiotic prophylaxis.
• Orthodontic Appliances.
• Immunological diseases or use of drugs that can affect oral tissues (phenytoin, cyclosporine), nifedipine, chronic use of nonsteroidal anti-inflammatory drugs.
• Refusal to participate in the study.

Sponsors & Collaborators

• University of Bari Aldo Moro: lead

Study Sites (1)

University of Bari Aldo Moro

Bari, 70124, Italy

Location

MeSH Terms

Conditions

Endometriosis; Periodontitis

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Saverio Capodiferro, Professor

  University of Bari Aldo Moro

  STUDY DIRECTOR

• Massimo Corsalini, Professor

  University of Bari Aldo Moro

  STUDY DIRECTOR

• Giuseppe D'Albis

  University of Bari Aldo Moro

  PRINCIPAL INVESTIGATOR

• Agneta Maria Teresa

  University of Bari Aldo Moro

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 18, 2024
• First Posted: December 31, 2024
• Study Start: January 1, 2023
• Primary Completion: June 1, 2023
• Study Completion: December 1, 2024
• Last Updated: January 1, 2025

Record last verified: 2024-12

Locations

IT (1)