The Use of AKR1B10 for Monitoring Postoperative Recurrence of Hepatocellular Carcinoma

NCT06750159 | Not Yet Recruiting

• 1 other identifier: I-24PJ2284
• Study Type: observational
• Target: 400
• Locations: 0 countries
• Sites: N/A

Brief Summary

Based on the clue that the serum marker AKR1B10 found in the investigators' previous study can be used as an effective indicator for detecting HCC and preHCC, the role and value of AKR1B10 as a new tumor marker for evaluating the recurrence monitoring of HCC after radical surgical resection needs further study, as to provide detailed clinical research data and scientific basis for improving the survival rate of HCC patients.

Conditions

Hepatocellular Carcinoma (HCC)

Outcome Measures

Primary Outcomes (1)

• post-operation recurrence or death

  From date of enrollment until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 5 years.

Interventions

No intervention (observational study) OTHER

no intervention(observational study)

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who have diagnosed with hepatocellular carcinoma

You may qualify if:

• Meets the diagnostic criteria of primary hepatocellular carcinoma.
• Meet the criteria for radical resection of hepatocellular carcinoma.
• No anti-cancer treatment before the first diagnosis.

You may not qualify if:

• Patients who are pregnant or nursing.
• Patients with incomplete clinical data, serological and imaging findings.
• Patients who were lost to follow-up before the observation endpoint.
• Complicated with serious heart, brain, lung, kidney, hematopoietic and other system diseases.

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Biospecimen

Retention: SAMPLES WITHOUT DNA

Residual serum of patients' routine blood tests

MeSH Terms

Conditions

Carcinoma, Hepatocellular

Interventions

Observation

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Liver Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Central Study Contacts

Shunda Du, Professor

CONTACT

86-18612671763; dushd@pumch.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Liver Surgery Department

Study Record Dates

• First Submitted: December 12, 2024
• First Posted: December 27, 2024
• Study Start: December 16, 2024
• Primary Completion: December 31, 2025
• Study Completion (Estimated): December 31, 2029
• Last Updated: December 27, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will share