Role of OCT & OCT Angiography in Patients With Posterior at the Uveitis Clinic of Assiut University Hospital.

NCT06743906 | Not Yet Recruiting DMC

• 1 other identifier: OCT & OCT posterior uveitis
• Study Type: observational
• Target: 25
• Locations: 0 countries
• Sites: N/A

Brief Summary

OCT angiography is a recent evaluation of OCT technology which combines the structural assessment of ocular tissues obtained by OCT image with visualization of blood flow within the vessels in imaged area. So combined structural and function image can be obtained by OCT angiography. Defferent type of uveitis often have specific OCT \& OCT angiography findingwhich deffer according to the involved ocular tissue and according to the type of inflammatory / infectious process that characterize them. The aim of study is to determine the role of OCT \& OCT angiography in assessment of retinal and choroidal architectural and vascular changes in patients with posterior uveitis.

Conditions

Uveitis, Posterior

Keywords

OCT & OCT angiography

Outcome Measures

Primary Outcomes (1)

• the choroidal thickness (CT) measurements

  The choroidal thickness (CT) measurements will be obtained from manual segmentation of OCT B-scans at the fovea for case numbers 1, 2, 4 and 5 and at the location of the choroiditis lesion

  baseline

Study Arms (1)

uveitis patient

participants will be recruited from the ophthalmology outpatient clinic of Assiut University Hospitals.- Patient with posterior uveitis (infectious or non-infectious posterior uveitis).

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

participants will be recruited from the ophthalmology outpatient clinic of Assiut University Hospitals.- Patient with posterior uveitis (infectious or non-infectious posterior uveitis).

You may qualify if:

• \- Patient age of greater than 18 years old.
• Patient can offer viable consent.
• Patient with posterior uveitis (infectious or non-infectious posterior uveitis).

You may not qualify if:

• \- Patient unable to offer viable consent.
• Patient unwilling to participate.
• Any coexistence retinal pathology: diabetic retinopathy, other causes of retinal vascular occlusion, traumatic retinopathy, traumatic maculopathy, other peripheral ischemic retinopathy e.g. sickles cell retinopathy.
• Presence of media opacity hindering appropriate scan.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Gupta V, Gupta P, Singh R, Dogra MR, Gupta A. Spectral-domain Cirrus high-definition optical coherence tomography is better than time-domain Stratus optical coherence tomography for evaluation of macular pathologic features in uveitis. Am J Ophthalmol. 2008 Jun;145(6):1018-1022. doi: 10.1016/j.ajo.2008.01.021. Epub 2008 Mar 17.

  PMID: 18343349 BACKGROUND

• Diniz B, Regatieri C, Andrade R, Maia A. Evaluation of spectral domain and time domain optical coherence tomography findings in toxoplasmic retinochoroiditis. Clin Ophthalmol. 2011;5:645-50. doi: 10.2147/OPTH.S20033. Epub 2011 May 17.

  PMID: 21629569 BACKGROUND

MeSH Terms

Conditions

Uveitis, Posterior; Ornithine Carbamoyltransferase Deficiency Disease

Condition Hierarchy (Ancestors)

Panuveitis; Uveitis; Uveal Diseases; Eye Diseases; Urea Cycle Disorders, Inborn; Brain Diseases, Metabolic, Inborn; Brain Diseases, Metabolic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Genetic Diseases, X-Linked; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Amino Acid Metabolism, Inborn Errors; Metabolism, Inborn Errors; Metabolic Diseases; Nutritional and Metabolic Diseases

Central Study Contacts

Ahmed Lotfy Mahmoud, resident doctor

CONTACT

+20 11 00571623; me7rek@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor at Assiut University hospital

Study Record Dates

• First Submitted: December 17, 2024
• First Posted: December 20, 2024
• Study Start: May 1, 2025
• Primary Completion: March 1, 2026
• Study Completion: May 1, 2026
• Last Updated: April 21, 2025

Record last verified: 2024-12