A Study of Mitral Annular Disjunction in Mitral Valve Prolapse Patients and Arrhythmia Risk

NCT06741709 | Not Yet Recruiting

• 1 other identifier: Mitral annulus disjunction
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the characteristics and prevalence of mitral annular disjunction in patients with mitral valve prolapse with severe mitral regurgitation (MR) at Assiut University Heart Hospital.

Conditions

Mitral Valve Prolapse; Mitral Valve Insufficiency

Keywords

Mitral annular disjunction

Outcome Measures

Primary Outcomes (1)

• Detect the prevalence of mitral annular disjunction in patients with mitral valve prolapse

  Detect the prevalence of mitral annular disjunction in patients with mitral valve prolapse

  six months

Eligibility Criteria

• Age: 18 Months+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

30

You may qualify if:

• All consecutive patients \> 18 years of age presenting to Assiut University Heart Hospital with MVP and more than moderate MR.

You may not qualify if:

• Previous mitral valve surgery.
• MVP due to infective endocarditis.
• Moderate or more significant aortic stenosis, aortic regurgitation or mitral stenosis.
• Congenital heart disease and poor image quality precluding accurate assessment of the mitral valve.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University

Asyut, Asyut Governorate, 71111, Egypt

Location

Related Publications (4)

• Hussain N, Bhagia G, Doyle M, Rayarao G, Williams RB, Biederman RWW. Mitral annular disjunction; how accurate are we? A cardiovascular MRI study defining risk. Int J Cardiol Heart Vasc. 2023 Nov 9;49:101298. doi: 10.1016/j.ijcha.2023.101298. eCollection 2023 Dec.

  PMID: 38035256 BACKGROUND

• Tison GH, Abreau S, Barrios J, Lim LJ, Yang M, Crudo V, Shah DJ, Nguyen T, Hu G, Dixit S, Nah G, Arya F, Bibby D, Lee Y, Delling FN. Identifying Mitral Valve Prolapse at Risk for Arrhythmias and Fibrosis From Electrocardiograms Using Deep Learning. JACC Adv. 2023 Aug;2(6):100446. doi: 10.1016/j.jacadv.2023.100446. Epub 2023 Aug 5.

  PMID: 37936601 BACKGROUND

• Donal E, Galli E, Letourneau T. Need for expertise in mitral valve regurgitation. Open Heart. 2019 Apr 28;6(1):e001039. doi: 10.1136/openhrt-2019-001039. eCollection 2019. No abstract available.

  PMID: 31168391 BACKGROUND

• Zoghbi WA, Adams D, Bonow RO, Enriquez-Sarano M, Foster E, Grayburn PA, Hahn RT, Han Y, Hung J, Lang RM, Little SH, Shah DJ, Shernan S, Thavendiranathan P, Thomas JD, Weissman NJ. Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation: A Report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr. 2017 Apr;30(4):303-371. doi: 10.1016/j.echo.2017.01.007. Epub 2017 Mar 14. No abstract available.

  PMID: 28314623 BACKGROUND

MeSH Terms

Conditions

Mitral Valve Prolapse; Mitral Valve Insufficiency

Condition Hierarchy (Ancestors)

Heart Valve Prolapse; Heart Valve Diseases; Heart Diseases; Cardiovascular Diseases

Central Study Contacts

Kerolos R. Ayad, MA

CONTACT

+2 01272872479; kerorezk37@gmail.com

Yousra M. Hamdy, Lecturer

CONTACT

+2 01003314748; Yousra.ghzally@med.aun.edu.eG

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor

Study Record Dates

• First Submitted: October 24, 2024
• First Posted: December 19, 2024
• Study Start: February 14, 2025
• Primary Completion (Estimated): October 30, 2026
• Study Completion (Estimated): December 30, 2026
• Last Updated: December 19, 2024

Record last verified: 2024-12

Locations

EG (1)