Comparison of Channel Esophagogastrostomy and Double Tract Reconstruction After Laparoscopic-assist Proximal Gastrectomy: a Propensity Score-Matched Analysis

NCT06741124 | Completed

• 2 other identifiers: NorthernJiangsuCEDTRCEDTR
• Study Type: observational
• Target: 99
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective cohort study enrolled adult patients who underwent LAPG between September 2020 and September 2023 at Northern Jiangsu People's Hospital. Patients were categorized into the CE group (CE anastomosis) and the DTR group (DTR anastomosis) based on the digestive tract reconstruction method after LAPG. Variables such as sex and BMI may influence the technical difficulty and clinical outcomes of LAPG. To minimize bias, propensity score (PS) matching was performed at a 1:2 ratio between the CE group and the DTR group.

Conditions

Gastric (Stomach) Cancer

Keywords

Proximal Gastrectomy; Channel Esophagogastrostomy; Double Tract Reconstruction

Outcome Measures

Primary Outcomes (1)

• Endoscopic reflux esophagitis

  Los Angeles classification

  Postoperative one year

Secondary Outcomes (1)

• PGSAS-45 questionnaires

  Postoperative one year

Other Outcomes (1)

• Nutritions status

  Postoperative one month, Postoperative three month, Postoperative nine month, Postoperative twelve month,

Study Arms (2)

Channel Esophagogastrostomy (CE)

Patients who underwent Channel Esophagogastrostomy reconstruction

Procedure: Channel Esophagogastrostomy

Double Tract Reconstruction (DTR)

Patients who underwent DTR reconstruction during LAPG

Procedure: Double Tract Reconstruction

Interventions

Channel Esophagogastrostomy PROCEDURE

Channel Esophagogastrostomy

Channel Esophagogastrostomy (CE)

Double Tract Reconstruction PROCEDURE

Double Tract Reconstruction

Double Tract Reconstruction (DTR)

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

adult patients who underwent LAPG between September 2020 and September 2023 at Northern Jiangsu People's Hospital. Patients who underwent CE reconstruction or DTR during LAPG;

You may qualify if:

• (1) Patients with a malignant tumor in the upper one-third of the stomach, diagnosed through endoscopy and pathology, with no distant metastases confirmed by multislice spiral computed tomography, and who underwent elective LAPG; (2) Patients who underwent CE reconstruction or DTR during LAPG; and (3) Patients available for postoperative follow-up.

You may not qualify if:

• (1) Patients who had received neoadjuvant radiotherapy or chemotherapy prior to surgery; (2) Emergency surgery patients; (3) Patients with concurrent malignancies; (4) Lost to follow-up patients.

Sponsors & Collaborators

• Northern Jiangsu People's Hospital: lead

Study Sites (1)

Northern Jiangsu People's Hospital

Yangzhou, Jiangsu, 225001, China

Location

Related Publications (2)

• Liu K, Yang K, Zhang W, Chen X, Chen X, Zhang B, Chen Z, Chen J, Zhao Y, Zhou Z, Chen L, Hu J. Changes of Esophagogastric Junctional Adenocarcinoma and Gastroesophageal Reflux Disease Among Surgical Patients During 1988-2012: A Single-institution, High-volume Experience in China. Ann Surg. 2016 Jan;263(1):88-95. doi: 10.1097/SLA.0000000000001148.

  PMID: 25647058 BACKGROUND

• Zhou J, Li R, Cheng Y, Zhao S, Wang J, Fu Y, Tian Z, Wang L, Wang W, Ren J, Wang D. Comparison of channel esophagogastrostomy and double tract reconstruction after laparoscopic-assisted proximal gastrectomy: a propensity score-matched analysis. Surg Endosc. 2025 Sep;39(9):5722-5732. doi: 10.1007/s00464-025-11978-w. Epub 2025 Jul 17.

  PMID: 40676300 DERIVED

MeSH Terms

Conditions

Stomach Neoplasms

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 16, 2024
• First Posted: December 18, 2024
• Study Start: September 1, 2020
• Primary Completion: September 1, 2023
• Study Completion: September 1, 2024
• Last Updated: January 10, 2025

Record last verified: 2020-09

Locations

CN (1)