Glycoprotein Matrix-Bound Iron Improves Iron Absorption

NCT06738199 | Completed

• 1 other identifier: GPMiron
• Study Type: interventional
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

A double-blind, randomized crossover study was conducted that evaluated absorption kinetics of 3 forms of dietary supplement iron by measuring iron levels in the blood after acute ingestion.

Conditions

Evaluation of Bioavailability of Supplemental Forms of Iron

Keywords

Bioavailability; iron; absorption; postbiotic

Outcome Measures

Primary Outcomes (1)

• plasma iron levels

  Blood levels were assessed to determine if absorption rates were different between the 3 arms (forms of iron). Blood samples were taken at 30-, 60-, 90-, 120-, 180-, 240-, 300-, 360-, 420-, and 480-minutes post-ingestion.

  8 hour absorption period.

Study Arms (3)

glycoprotein matrix iron

EXPERIMENTAL

Acute glycoprotein matrix iron was ingested to assess blood appearance levels from pre and at 30-, 60-, 90-, 120-, 180-, 240-, 300-, 360-, 420-, and 480-minutes post-ingestion.

Dietary Supplement: dietary iron supplementation

ferrous bisglycinate chelate iron

EXPERIMENTAL

Acute ferrous bisglycinate chelate iron was ingested to assess blood appearance levels from pre and at 30-, 60-, 90-, 120-, 180-, 240-, 300-, 360-, 420-, and 480-minutes post-ingestion.

Dietary Supplement: dietary iron supplementation

ferrous fumarate iron

EXPERIMENTAL

Acute ferrous fumarate iron was ingested to assess blood appearance levels from pre and at 30-, 60-, 90-, 120-, 180-, 240-, 300-, 360-, 420-, and 480-minutes post-ingestion.

Dietary Supplement: dietary iron supplementation

Interventions

dietary iron supplementation DIETARY_SUPPLEMENT

This study aimed to compare the absorption kinetics of iron bound to a glycoprotein matrix (GPM) with those of ferrous bisglycinate chelate (FBC) and ferrous fumarate (FF).

ferrous bisglycinate chelate iron; ferrous fumarate iron; glycoprotein matrix iron

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participants had to have a normal body weight \[body mass index (BMI) of 19-24.99 kg/m2\] and engage in recreational physical activity, as defined by the American College of Sports Medicine guidelines.
• Participants must be healthy and have no diagnosed chronic disease conditions

You may not qualify if:

• Participants were not allowed to consume any nutritional supplements known to affect the measures of the current study for at least 6 weeks prior to participation, including pro-, post- and prebiotics, as well as digestive enzymes.
• Individuals who were currently being treated for or diagnosed with a gastrointestinal, cardiac, respiratory, circulatory, musculoskeletal, metabolic, immune, autoimmune, psychiatric, hematological, neurological, or endocrinological disorder.
• Participants whose body mass had deviated by more than 2% in the previous 30 days
• Participants who were unwilling to abstain from alcohol, nicotine, and caffeine for 12 hours prior to each visit.

Sponsors & Collaborators

• University of Mary Hardin-Baylor: lead
• Pharmachem Innovations: collaborator

Study Sites (1)

Human Performance Lab

Belton, Texas, 76513, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: lab staff that did the analysis and lead author that performed statistical analyses
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 12, 2024
• First Posted: December 17, 2024
• Study Start: February 1, 2024
• Primary Completion: April 22, 2024
• Study Completion: April 22, 2024
• Last Updated: December 17, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: From date of possible manuscript publication and 2 years following that publication date.
• Access Criteria: Research can contact the listed corresponding author in published manuscript of this data.

Locations

US (1)