Cellular and Molecular Analysis of Synovial Tissue of Patients With Arthritis

NCT06737952 | Not Yet Recruiting

• 1 other identifier: 2024-02011; mu24kyburz
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to study the inflammatory response in various forms of arthritis.

Conditions

Arthritis; Arthritis, Rheumatoid; Osteoarthritis; Spondyloarthritis; Synovitis

Keywords

ultrasound-guided synovial biopsies (UGSB); inflammatory response; synovial biopsy

Outcome Measures

Primary Outcomes (3)

• Grade of synovitis

  assessed by the Krenn score in the hematoxylin and eosin staining (Score 0-3, 0=normal, 3=severe)

  immediately after collection to study completion, up to 5 years

• classification pathotypes

  immunohistochemical staining with cell type specific markers including CD15, CD68, CD3, CD20, CD138 of the collected tissues from different arthritis subtypes

  immediately after collection to study completion, up to 5 years

• comparing transcriptomic signature

  single-cell RNA sequencing of collected tissues from different arthritis subtypes to identify disease specific biomarkers.

  immediately after collection to study completion, up to 5 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

arthritis patients

You may qualify if:

• Age \>18 years
• Clinically relevant arthritis in one or more joints as assessed by the treating rheumatologist, including RA, SpA, connective tissue disease and OA.

You may not qualify if:

• Known allergies to local anesthetics
• Family history of bleeding, history of increased bleeding tendency or prolonged bleeding, current treatment with oral anticoagulants or platelet aggregation inhibitors; Quick \< 65%, international normalised ratio (INR) ≥ 1.3, thrombocyte count \< 100'000/μl, activated partial thromboplastin time (aPTT) \> 37 sec
• Inability or insufficient knowledge of project language to understand the information given in the informed consent form

Sponsors & Collaborators

• University Hospital, Basel, Switzerland: lead

Biospecimen

Retention: SAMPLES WITH DNA

* Synovial tissue samples collected from inflamed joints, samples at least 6 mm in size with typical characteristics of synovium * Synovial fluid * peripheral blood

MeSH Terms

Conditions

Arthritis; Arthritis, Rheumatoid; Osteoarthritis; Spondylarthritis; Synovitis

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Spondylitis; Spinal Diseases; Bone Diseases

Study Officials

• Diego Kyburz, Prof. Dr.

  Universitätsspital Basel

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Diego Kyburz, Prof. Dr.

CONTACT

+41 61 328 74 81; diego.kyburz@usb.ch

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 11, 2024
• First Posted: December 17, 2024
• Study Start: May 1, 2025
• Primary Completion (Estimated): December 1, 2029
• Study Completion (Estimated): December 1, 2029
• Last Updated: April 11, 2025

Record last verified: 2025-04