NCT06735989

Brief Summary

The primary aim of this study is to evaluate the short (immediate) and mid-term (one month) impact of moral (vs non-moral) reasoning interventions on the moral justification abilities in non-expert subjects. Such an impact will be assessed by observing quantitative changes (on 1 to 4 points scale) of qualitative variables in the moral justification expressed by the subjects.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
86

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Nov 2022

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 18, 2022

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 19, 2024

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

July 31, 2024

Completed
5 months until next milestone

First Posted

Study publicly available on registry

December 16, 2024

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 13, 2025

Completed
Last Updated

December 23, 2025

Status Verified

December 1, 2025

Enrollment Period

1.3 years

First QC Date

July 31, 2024

Last Update Submit

December 16, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Short and mid-term (one month) impact of moral vs non-moral reasoning interventions on moral justification abilities in non-expert subjects when performing a moral dilemma.

    The primary aim of this study is to evaluate the short (immediate) and mid-term (one month) impact of moral (vs non-moral) reasoning interventions on the moral justification abilities in non-expert subjects. Such an impact will be assessed by observing quantitative changes (on a 0 to 3 points scale) in the moral justifications expressed by the subjects in six domains: empirical competence, conceptual competence, logical coherence, sympathetic imagination, bias reduction, openness to revision of opinions.

    Baseline, 5 weeks

Secondary Outcomes (3)

  • Relationship between brain BOLD activity during task-based fMRI and changes in moral justification abilities.

    Baseline, 5 weeks

  • Relationship between brain BOLD activity during task-based fMRI and agreement with moral statements.

    Baseline, 5 weeks

  • Relationship between brain BOLD activity during task-based fMRI and confidence post-intervention.

    Baseline, 5 weeks

Study Arms (2)

Moral

EXPERIMENTAL

The Moral group will read a short text explaining the meaning and function of moral justification, and outlining brief descriptions of six morally relevant factors. The Moral group will then attend a 1h30 lecture on moral reasoning.

Other: Lecture on moral reasoning

Non-moral

ACTIVE COMPARATOR

The Non-moral will read a short text explaining the meaning and function of argumentation, and outlining brief descriptions of six logical and argumentative principles. The Non-moral group will then attend a 1h30 lecture on (non-moral) logical reasoning.

Other: Lecture on logical reasoning

Interventions

One and a half-hour long lecture on logical and argumentative principles

Non-moral

One and a half-hour long lecture on moral justification and moral reasoning

Moral

Eligibility Criteria

Age18 Years - 26 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • University students (other than Philosophy) within the first 3 years
  • Aged between 18 and 26 years old
  • Italian speakers
  • Oral and written informed consent to study participation

You may not qualify if:

  • A current psychiatric condition
  • Contraindications to MRI study (cardiac pacemakers; metal splinters or fragments; metal protheses not compatible with the magnetic field; claustrophobia; women who are pregnant or intending to become pregnant during the study; breastfeeding women).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

IRCCS San Raffaele

Milan, Italy, 20132, Italy

Location

Related Publications (9)

  • Greene JD. The rat-a-gorical imperative: Moral intuition and the limits of affective learning. Cognition. 2017 Oct;167:66-77. doi: 10.1016/j.cognition.2017.03.004. Epub 2017 Mar 23.

    PMID: 28343626BACKGROUND
  • Greene JD, Sommerville RB, Nystrom LE, Darley JM, Cohen JD. An fMRI investigation of emotional engagement in moral judgment. Science. 2001 Sep 14;293(5537):2105-8. doi: 10.1126/science.1062872.

    PMID: 11557895BACKGROUND
  • Haidt J. The emotional dog and its rational tail: a social intuitionist approach to moral judgment. Psychol Rev. 2001 Oct;108(4):814-34. doi: 10.1037/0033-295x.108.4.814.

    PMID: 11699120BACKGROUND
  • Kahneman D, Klein G. Conditions for intuitive expertise: a failure to disagree. Am Psychol. 2009 Sep;64(6):515-26. doi: 10.1037/a0016755.

    PMID: 19739881BACKGROUND
  • Klenk M, Sauer H. Moral Judgement and Moral Progress: The Problem of Cognitive Control. Philos Psychol. 2021 Jul 2;34(7):938-961. doi: 10.1080/09515089.2021.1931670. eCollection 2021.

    PMID: 34556899BACKGROUND
  • Rozin P, Haidt J, Fincher K. Psychology. From oral to moral. Science. 2009 Feb 27;323(5918):1179-80. doi: 10.1126/science.1170492. No abstract available.

    PMID: 19251619BACKGROUND
  • Schaefer GO, Savulescu J. Procedural Moral Enhancement. Neuroethics. 2019;12(1):73-84. doi: 10.1007/s12152-016-9258-7. Epub 2016 Apr 20.

    PMID: 30956726BACKGROUND
  • Schwitzgebel E, Cokelet B, Singer P. Do ethics classes influence student behavior? Case study: Teaching the ethics of eating meat. Cognition. 2020 Oct;203:104397. doi: 10.1016/j.cognition.2020.104397. Epub 2020 Jul 25.

    PMID: 32721655BACKGROUND
  • Schwitzgebel E, Cushman F. Philosophers' biased judgments persist despite training, expertise and reflection. Cognition. 2015 Aug;141:127-37. doi: 10.1016/j.cognition.2015.04.015. Epub 2015 May 14.

    PMID: 25981733BACKGROUND

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Masking Details
Blinding will be maintained for allocation concealment, which will be carried out through closed and opaque mails by a blind operator. Subjects will be labelled with a numerical code to ensure anonymisation. Subjects, teachers, evaluators and statisticians will be blind to allocation. Specifically, teachers of both groups will be not informed about the aim of the study. They will be provided with specular material for the seminar (same structure and number of slides). They will be only informed to not answer to specific questions about dilemmas. Subjects of a group will be informed that the other group is attending a seminar on "reasoning". They will be separated until the end of the post-test phase.
Purpose
OTHER
Intervention Model
PARALLEL
Model Details: Intervention study, monocentric, randomized, double-blind, and multiparametric.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Prof.

Study Record Dates

First Submitted

July 31, 2024

First Posted

December 16, 2024

Study Start

November 18, 2022

Primary Completion

February 19, 2024

Study Completion

October 13, 2025

Last Updated

December 23, 2025

Record last verified: 2025-12

Locations