Probing the Role of Feature Dimension Maps in Visual Cognition: Impact of Working Memory Maintenance (Expt 2.3)

NCT06733467 | Completed

• 2 other identifiers: 5-24-0443: 2.3R01EY035300
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

How does one know what to look at in a scene? Imagine a "Where's Waldo" game - it's challenging to find Waldo because there are many 'salient' locations in the picture, each vying for one's attention. One can only attend to a small location on the picture at a given moment, so to find Waldo, one needs to direct their attention to different locations. One prominent theory about how one accomplishes this claims that important locations are identified based on distinct feature types (for example, motion or color), with locations most unique compared to the background most likely to be attended. An important component of this theory is that individual feature dimensions (again, color or motion) are computed within their own 'feature maps', which are thought to be implemented in specific brain regions. However, whether and how specific brain regions contribute to these feature maps, along with their role in supporting memory of visual information over brief delays, remains unknown. The goal of this study is to determine how brain regions that respond strongly to different feature types (color and motion) and which encode spatial locations of visual stimuli contribute to memory of visual features. Based on previous studies, the investigators hypothesize that feature-selective brain regions act as neural feature dimension maps, and thus encode representations of relevant location(s) based on their preferred feature dimension, such that the stimulus representation in the most relevant feature map is maintained over a memory delay period to support adaptive behavior. The investigators will scan healthy human participants using functional MRI (fMRI) in a repeated-measures design while they view and remember different features of visual stimuli (e.g., color or motion). The investigators will employ state-of-the-art multivariate analysis techniques that allow them to reconstruct an 'image' of the stimulus representation encoded by each brain region to dissect how neural tissue identifies salient locations. Each participant will recall the remembered feature value (color or motion) of a stimulus presented in the periphery. Across trials the investigators will manipulate the remembered feature value (color, motion, or attend to nothing). This manipulation will help the investigators fully understand these critical relevance computations in the healthy human visual system.

Conditions

Basic Science: Visual Attention in Healthy Participants; Basic Science: Neural Representations of Location

Outcome Measures

Primary Outcomes (3)

• Blood Oxygenation Level Dependent (BOLD) fMRI signal

  The investigators will use BOLD activation patterns measured from each retinotopic ROI to fit quantitative models of spatial encoding. These models will be used to reconstruct stimulus representations on experimental trials to quantify how stimulus representations are encoded in each brain region studied, and how these representations change across experimental manipulations. These measurements will be used to test the impact of stimulus manipulations on stimulus representations in different brain regions.

  Through study completion, an average of two weeks

• Gaze position

  The investigators will use the measured gaze position in (x,y) coordinates to verify stable fixation throughout the experiment. Trials with poor fixation performance may be excluded from further analyses.

  Through study completion, an average of two weeks

• Behavioral response (button press)

  On remember-color trials, participants will adjust a dot array to match the precise color of the dots at the beginning of the trial (adjust hue through a circular colorspace with buttons moving in each direction). On remember-motion trials, participants will adjust a dot array to match the precise motion direction at the beginning of the trial (adjust motion around the circle with buttons moving in each direction). The investigators will ensure participants are performing the task as instructed by assessing the accuracy of their behavioral responses. The full response trajectory and final response value will be recorded.

  Through study completion, an average of two weeks

Study Arms (1)

Manipulations of Visual Working Memory (Expt 2.3)

EXPERIMENTAL

Participants will be shown a colorful moving dot stimulus at a random location in the periphery while maintaining fixation. After a 12 sec delay period where nothing is presented on the screen, they will be shown a new dot array at the dot array location and they will have to adjust either the color/motion of the array to match what was shown at the beginning of the trial (or do nothing if it is the remember nothing condition).

Other: Stimulus properties: remembered feature

Interventions

Stimulus properties: remembered feature OTHER

The feature used to determine which stimulus feature to remember to will be varied across trials using a letter cue (M = remember-motion; C = remember-color; 0 = remember nothing)

Manipulations of Visual Working Memory (Expt 2.3)

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• between 18 and 55 years of age
• normal or corrected-to-normal vision

You may not qualify if:

• neurological disease based on self-report
• implanted medical devices (e.g., cardiac pacemaker; metallic aneurism clip)
• non-removable metallic piercings
• metal fragments in the body (e.g., from welding)
• pregnant and have a chance of being pregnant (if female)
• history of claustrophobia
• history of hearing loss/damage

Sponsors & Collaborators

• University of California, Santa Barbara: lead
• National Eye Institute (NEI): collaborator

Study Sites (1)

University of California, Santa Barbara

Santa Barbara, California, 93117, United States

Location

Related Publications (17)

• Mackey WE, Winawer J, Curtis CE. Visual field map clusters in human frontoparietal cortex. Elife. 2017 Jun 19;6:e22974. doi: 10.7554/eLife.22974.

  PMID: 28628004 BACKGROUND

• Hallenbeck GE, Sprague TC, Rahmati M, Sreenivasan KK, Curtis CE. Working memory representations in visual cortex mediate distraction effects. Nat Commun. 2021 Aug 5;12(1):4714. doi: 10.1038/s41467-021-24973-1.

  PMID: 34354071 BACKGROUND

• Sprague TC, Itthipuripat S, Vo VA, Serences JT. Dissociable signatures of visual salience and behavioral relevance across attentional priority maps in human cortex. J Neurophysiol. 2018 Jun 1;119(6):2153-2165. doi: 10.1152/jn.00059.2018. Epub 2018 Feb 28.

  PMID: 29488841 BACKGROUND

• Sprague TC, Adam KCS, Foster JJ, Rahmati M, Sutterer DW, Vo VA. Inverted Encoding Models Assay Population-Level Stimulus Representations, Not Single-Unit Neural Tuning. eNeuro. 2018 Jun 5;5(3):ENEURO.0098-18.2018. doi: 10.1523/ENEURO.0098-18.2018. eCollection 2018 May-Jun. No abstract available.

  PMID: 29876523 BACKGROUND

• Sprague TC, Boynton GM, Serences JT. The Importance of Considering Model Choices When Interpreting Results in Computational Neuroimaging. eNeuro. 2019 Dec 20;6(6):ENEURO.0196-19.2019. doi: 10.1523/ENEURO.0196-19.2019. Print 2019 Nov/Dec.

  PMID: 31772033 BACKGROUND

• Laumann TO, Gordon EM, Adeyemo B, Snyder AZ, Joo SJ, Chen MY, Gilmore AW, McDermott KB, Nelson SM, Dosenbach NU, Schlaggar BL, Mumford JA, Poldrack RA, Petersen SE. Functional System and Areal Organization of a Highly Sampled Individual Human Brain. Neuron. 2015 Aug 5;87(3):657-70. doi: 10.1016/j.neuron.2015.06.037. Epub 2015 Jul 23.

  PMID: 26212711 BACKGROUND

• Allen EJ, St-Yves G, Wu Y, Breedlove JL, Prince JS, Dowdle LT, Nau M, Caron B, Pestilli F, Charest I, Hutchinson JB, Naselaris T, Kay K. A massive 7T fMRI dataset to bridge cognitive neuroscience and artificial intelligence. Nat Neurosci. 2022 Jan;25(1):116-126. doi: 10.1038/s41593-021-00962-x. Epub 2021 Dec 16.

  PMID: 34916659 BACKGROUND

• Fedorenko E. The early origins and the growing popularity of the individual-subject analytic approach in human neuroscience. Current Opinion in Behavioral Sciences. 2021; 40:105-112.

  BACKGROUND

• Naselaris T, Allen E, Kay K. Extensive sampling for complete models of individual brains. Current Opinion in Behavioral Sciences. 2021; 40:45-51.

  BACKGROUND

• Poldrack RA. Diving into the deep end: a personal reflection on the MyConnectome study. Current Opinion in Behavioral Sciences. 2021; 40:1-4.

  BACKGROUND

• Pritschet L, Taylor CM, Santander T, Jacobs EG. Applying dense-sampling methods to reveal dynamic endocrine modulation of the nervous system. Curr Opin Behav Sci. 2021 Aug;40:72-78. doi: 10.1016/j.cobeha.2021.01.012. Epub 2021 Feb 25.

  PMID: 35369044 BACKGROUND

• Gratton C, Nelson SM, Gordon EM. Brain-behavior correlations: Two paths toward reliability. Neuron. 2022 May 4;110(9):1446-1449. doi: 10.1016/j.neuron.2022.04.018.

  PMID: 35512638 BACKGROUND

• Smith PL, Little DR. Small is beautiful: In defense of the small-N design. Psychon Bull Rev. 2018 Dec;25(6):2083-2101. doi: 10.3758/s13423-018-1451-8.

  PMID: 29557067 BACKGROUND

• Sprague TC, Serences JT. Attention modulates spatial priority maps in the human occipital, parietal and frontal cortices. Nat Neurosci. 2013 Dec;16(12):1879-87. doi: 10.1038/nn.3574. Epub 2013 Nov 10.

  PMID: 24212672 BACKGROUND

• Itthipuripat S, Vo VA, Sprague TC, Serences JT. Value-driven attentional capture enhances distractor representations in early visual cortex. PLoS Biol. 2019 Aug 9;17(8):e3000186. doi: 10.1371/journal.pbio.3000186. eCollection 2019 Aug.

  PMID: 31398186 BACKGROUND

• Poltoratski S, Tong F. Resolving the Spatial Profile of Figure Enhancement in Human V1 through Population Receptive Field Modeling. J Neurosci. 2020 Apr 15;40(16):3292-3303. doi: 10.1523/JNEUROSCI.2377-19.2020. Epub 2020 Mar 5.

  PMID: 32139585 BACKGROUND

• Poltoratski S, Ling S, McCormack D, Tong F. Characterizing the effects of feature salience and top-down attention in the early visual system. J Neurophysiol. 2017 Jul 1;118(1):564-573. doi: 10.1152/jn.00924.2016. Epub 2017 Apr 5.

  PMID: 28381491 BACKGROUND

Study Officials

• Tommy C Sprague

  University of California, Santa Barbara

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: Participants will typically be unaware of the conditions presented, though because these involve manipulations of stimuli or task demands, they may be aware of the manipulation. This is not expected to impact the primary outcome measures (e.g., BOLD signal activation patterns).
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This is a basic science study in which all participants will participate in all task conditions within each experiment (repeated-measures design).

Study Record Dates

• First Submitted: December 10, 2024
• First Posted: December 13, 2024
• Study Start: April 16, 2023
• Primary Completion: February 5, 2025
• Study Completion: February 5, 2025
• Last Updated: April 22, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
• Time Frame: Data will be available indefinitely beginning with publication of results
• Access Criteria: Processed fMRI data and raw behavioral/eyetracking data will be publicly available on the lab's Open Science Framework page (https://osf.io/ufjzl/), and analysis code will be available on GitHub (an online tool for storing and managing code; github.com/SpragueLab). Raw, unprocessed fMRI data will be made available upon justifiable request from qualified researchers

Locations

US (1)