Evaluation of Grass Pollen Sensitization Among Professionals Exposed or Not Exposed to Flour

NCT06727825 | Completed

• 1 other identifier: GRAMIPRO
• Study Type: observational
• Target: 403
• Locations: 1 country
• Sites: 1

Brief Summary

Occupational asthma are a major etiology of allergic asthma, especially among manual labor. The baker job exposes to significant level of flour. Some of allergenic components at work have simitudes with environmental allergens, for example cereals flour with gramineous pollens. GRAMIPRO is a retrospective cohort study that analyzes data from one specialized center at Créteil in the Paris region. The primary goal is to assess Participants include women and men aged over 18 years old at the time of their first consultation in the Occupational and Environmental Pathology Department of Créteil between April 2011 and July 2023, in order to explore asthma from an allergological perspective, patients working as bakers, pastry chefs, or restaurant workers, who are aware of exposed and patients in other professions; asthmatic patients with or without associated rhinitis. Exclusions apply for patients who opposing to participate, patients without asthma symptoms; and patients who did not consult for the first time in the given period. Data will be stored, anonymized, and analyzed using EasyMedStat. Data collection is scheduled between January 1 and 31, 2025 This research aims to o explore the factors that may influence the occurrence and severity of flour-induced allergic asthma symptoms in professionals exposed to this allergen, in order to consider prevention strategies and tools to advise individuals pursuing careers that expose them to flour. This study is intended for allergists, occupational physicians, general practitioners, and pulmonologists.

Conditions

Asthma; Sensitization

Keywords

Wheat flour; Occupational asthma; Grasses

Outcome Measures

Primary Outcomes (1)

• impact of the prevalence of pollen grass sensitization in professionals with asthma, whether or not associated with allergic rhinitis, and exposed to flour or other allergens besides flour.

  Day1

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who consulted between April 2011 and July 2023 for an occupational asthma exposed to flour or not at work

You may qualify if:

• patients who consulted between April 2011 and July 2023 for an occupational asthma
• active subjects
• Over 18 years at the first consultation with no upper limit
• Having not expressed their opposition to participate in the study

You may not qualify if:

• patients who opposing to participate in study
• patients without asthma symptoms
• patients who did not consult for the first time in the given period.
• Patient without occupational activity the day of the first consult or in the past

Sponsors & Collaborators

• Centre Hospitalier Intercommunal Creteil: lead

Study Sites (1)

Centre Hospitalier Intercommunal de Créteil

Créteil, 94000, France

Location

MeSH Terms

Conditions

Asthma; Asthma, Occupational

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Occupational Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 6, 2024
• First Posted: December 11, 2024
• Study Start: January 2, 2025
• Primary Completion: March 28, 2025
• Study Completion: March 28, 2025
• Last Updated: December 15, 2025

Record last verified: 2025-12

Locations

FR (1)