Brain Network Connectivity of Patients With Metabolic Diseases

NCT06725589 | Completed

• 1 other identifier: SYSKY-2024-706-01
• Study Type: observational
• Target: 690
• Locations: 1 country
• Sites: 1

Brief Summary

The global prevalence of metabolic diseases, including hypertension, type 2 T2DM mellitus (T2DM), gout and obesity, has risen over the past two decades. Brain controls human behavior and metabolism in organisms. It will be very interesting to explore whether there are similarities or relations among different metabolic diseases and how brain might be involved in the progression of different metabolic diseases. We analyzed the PET-CT images and clinical biological markers of 112 cases of hypertension, 56 cases of T2DM, 11 cases of obesity, 14 cases of gout, and 497 cases without the above diseases. Standardized uptake value ratios (SUVRs) were extracted from different brain regions according to AAL brain atlas using Spatial-Normalization-of-Brain-PET-Images. Partial correlation analysis was used to analyze the correlation of the SUVRs of different brain regions with clinical biological markers by controlling sex, age and BMI. Brain network metabolic connectivity was analyzed using Permutation\_IHEP software and visualized using BrainNet Viewer.

Conditions

Metabolic Disease

Outcome Measures

Primary Outcomes (1)

• the correlation between metabolic changes in different brain regions and blood test results in patients without metabolic diseases, hypertension, T2DM, gout and obesity

  2024.01-2024.06

Study Arms (1)

hypertension, T2DM, obesity, gout, and patients without the above diseases

hypertension, T2DM, obesity, gout, and patients without the above diseases

Other: metabolic disease

Interventions

metabolic disease OTHER

metabolic disease

hypertension, T2DM, obesity, gout, and patients without the above diseases

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent brain PET-CT examination in Sun Yat-sen Memorial Hospital from January 2018 to June 2024 and met our inclusion and exclusion criteria were included in the analysis. About 690 patients were included.

You may qualify if:

• Patients who underwent brain PET-CT in Sun Yat-sen Memorial Hospital from January 2018 to June 2024

You may not qualify if:

• Brain lesions, including patients with brain atrophy, cerebral ischemia and trauma, epilepsy, brain tumors, brain trauma, and psychiatric disorders; Patients with missing medical history or brain imaging data; Patients with tumor.

Sponsors & Collaborators

• Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University: lead

Study Sites (1)

Sun Yat-Sen Memorial Hospital

Guangzhou, China

Location

MeSH Terms

Conditions

Metabolic Diseases

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 5, 2024
• First Posted: December 10, 2024
• Study Start: January 1, 2024
• Primary Completion: June 30, 2024
• Study Completion: June 30, 2024
• Last Updated: December 10, 2024

Record last verified: 2024-12

Locations

CN (1)