VRSTPWA
Can Immersive Virtual Reality Magnify Treatment Outcomes of Script Training on Cantonese Speakers with Chronic Aphasia: a Randomized Controlled Trial
Sponsor study identifier
interventional
105
0 countries
N/A
Study Start
June 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
December 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The goal of this RCT is to investigate if computerized script training may promote functional communication and nonverbal cognitive functions of Cantonese-speaking PWA, and whether VR may further magnify the treatment outcomes. The main research questions are:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 3, 2024
Actual (reported)December 9, 2024
Actual (reported)June 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
June 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Percentage accuracy of treatment probe correctly produced
Participant's production accuracy of the trained scripts in read-aloud and no-cue conditions.
From baseline up to 8-week post training
Time to produce each of the scripts in the treatment probe
Participant's production time of the trained scripts in read-aloud and no-cue conditions.
From baseline up to 8-week post training
Number of sessions to reach performance criteria in session probe
From baseline up to 8-week post training
Cantonese version of the Western Aphasia Battery (CAB) to measure aphasia severity
From baseline up to 8-week post training
Cantonese version of the Amsterdam-Nijmegen Everyday Language Test to measure verbal communication effectiveness in conversation via 20 culturally appropriate scenarios
From baseline up to 8-week post training
Cantonese version of the 20-item Communication Outcome after Stroke (Can-COAST) as a self-reported outcome on communication and quality of life
From baseline up to 8-week post training
Subtest 1 (map search) and 3 (elevator counting) of Test of Everyday Attention to assess attention
From baseline up to 8-week post training
Digit span forward and backward task to assess verbal short-term and working memory
From baseline up to 8-week post training
The PWA will wear a head-mounted VR device (e.g., Metaverse Oculus Quest 2 or other commercially available devices) for 30 minutes, which intends to create an immersive environment for training. Scripts trained in the computerized script training program in a particular session will be practiced. Cinematic 360˚ photo-real scenarios of daily contexts such as a restaurant or a grocery store will be displayed in the device while a communication partner, e.g., a waiter in the restaurant or a shopkeeper of a grocery store will initiate the conversation by producing the corresponding part of the script. The PWA will be given time to respond. Upon the completion of PWA's respond, the next conversational turn will be initiated. The clinical assistant, who accompanies the PWA in the entire training session, will control the flow of the 360 ˚ videos.
Wong WWS, Li DSP, Fong KNK, Ng PHF, Kwok HTK. Can immersive virtual reality magnify treatment outcomes of computerized script training on Cantonese speakers with chronic aphasia? Protocol of a randomized controlled trial. PLoS One. 2026 Jun 2;21(6):e0350390. doi: 10.1371/journal.pone.0350390. eCollection 2026.
Winsy WS Wong, PhD
The Hong Kong Polytechnic University
First Submitted
December 3, 2024
First Posted
December 9, 2024
Study Start
June 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
December 2027
The flow of training is identical to the VR condition, except that photos depicting the scenarios and prerecorded conversational turns will be presented to the PWA on a computer screen with the same procedures mentioned in the VR condition.
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Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
March 13, 2025
Record last verified: 2024-08
The IPD, together with the study protocol, will be shared in an open-access data repository (e.g., OSF).
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Source: ClinicalTrials.gov.
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