Evaluation of Gas Humidification Practices in Patients Under Invasive Mechanical Ventilation

NCT06719258 | Recruiting

• 1 other identifier: 2022-3714
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

When mechanical ventilation is initiated, a humidification method should be chosen. There is two methods: heat and humidity exchanger filters or heated humidity. The second method is recognized to be more efficient, but many external factors can influence its performance. Insufficient humidity results in observable problems, such as difficult management of respiratory secretions. The study compare two heated humidifiers already used in ICU. Data will be collected retrospectively from June 1, 2021.

Conditions

Humidifier Lung; Mechanical Fragility; Respiratory Complication

Outcome Measures

Primary Outcomes (5)

• Endotracheal tube occlusion requiring emergency tube change

  Under-humidification episodes are defined as follows: \- Occurence of endotracheal tube occlusion requiring emergency tube change

  At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)

• Bronchoscopy

  Under-humidification episodes are defined as follows: \- Occurence of performing a bronchoscopy for a suspected sub-occlusion (thick or sticky secretions), and the total number of bronchoscopies performed per patient

  At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)

• Tracheal saline instillations

  Under-humidification episodes are defined as follows: \- Occurence of tracheal saline instillations due to sticky secretions or suspected endotracheal tube sub-occlusion

  At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)

• Thick secretions

  Under-humidification episodes are defined as follows: \- Occurence of tracheal secretions describe at thick secretions (rated at 5 on the secretions scale used at the hospital) or "sticky secretions" if specified

  At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)

• Change humidifier settings

  Under-humidification episodes are defined as follows: \- The number of operations required to change humidifier settings if the plate temperature is below 62 degrees Celcius (with the MR850).

  At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)

Secondary Outcomes (1)

• Other elements that may be influenced by the quality of the humidification used during mechanical ventilation

  At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)

Study Arms (2)

MR850

20 subjects on this heating humidifier (Fisher \& Paykel MR850).

Device: MR850

FP950

20 subjects on this heating humidifier (Fisher \& Paykel FP950).

Device: FP950

Interventions

MR850 DEVICE

This humidifier will be used straight away for patients whose intubation is expected to last longer than 24 hours.

MR850

FP950 DEVICE

This humidifier will be used straight away for patients whose intubation is expected to last longer than 24 hours.

FP950

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patient in ICU on ventilation will be consider.

You may qualify if:

• ≥ 18 years old
• Admitted to intensive care
• Under invasive mechanical ventilation with the usual indications for the use of a heated humidifier (prolonged invasive mechanical ventilation and / or protective ventilation requiring high respiratory rates.

You may not qualify if:

• Mechanical venitilation immediately after surgery (\<24h)
• Imminent extubation or planned intubation of very short duration (\<24h)
• Enrolled in the SAVE-ICU study in the group receiving volatile agents with the AnaConDa system.

Sponsors & Collaborators

• Laval University: lead

Study Sites (1)

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Québec, Quebec, G1V4G5, Canada

RECRUITING

Central Study Contacts

François Lellouche

CONTACT

418-656-8711; francois.lellouche@criucpq.ulaval.ca

Pierre-Alexandre Bouchard

CONTACT

418-656-8711; pierre-alexandre.bouchard@criucpq.ulaval.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 20, 2024
• First Posted: December 5, 2024
• Study Start: September 20, 2024
• Primary Completion: December 1, 2025
• Study Completion (Estimated): July 1, 2026
• Last Updated: August 28, 2025

Record last verified: 2025-08

Locations

CA (1)