A Comparison Study of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING
UP-RISING
Comparison of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING
1 other identifier
observational
678
1 country
53
Brief Summary
This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care This is a mono-country, prospective, multi-center observational study in patients with moderate to severe active RA receiving UPA or TNFi therapy. Around 678 participants will be enrolled in approximately 80 sites in Germany. Study recruitment will last approximately 24 months, and the study participation time will be up to 24 months, for a total study duration of approximately 48 months.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2024
Longer than P75 for all trials
53 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 7, 2024
CompletedFirst Submitted
Initial submission to the registry
November 27, 2024
CompletedFirst Posted
Study publicly available on registry
December 2, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2028
February 17, 2026
February 1, 2026
4.1 years
November 27, 2024
February 12, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Retention Rate of UPA vs TNFi
Time to the discontinuation of Upadacitinib. Time to the discontinuation of Tumor Necrosis Factor Inhibitor treatment
Up to approximately 24 months
Study Arms (2)
Upadacitinib
Participants will receive upadacitinib as prescribed by their physician according to local label.
Tumor Necrosis Factor Inhibitor-Treatment
Participants will receive a tumor necrosis factor inhibitor treatment as prescribed by their physician according to local label.
Eligibility Criteria
Participants with moderate to severe active Rheumatoid Arthritis receiving Upadcitinib or a Tumor necrosis factor inhibitor treatment.
You may qualify if:
- Current or Past participants with a confirmed diagnosis of moderate to severe active RA upon judgement of the treating physician.
- Physician decision on participant treatment with Upadacitinib (UPA) or tumor necrosis factor inhibitor (TNFi) must have been reached prior to and independently of recruitment in the study
- UPA or TNFi prescribed in accordance with the applicable approved label and local regulatory and reimbursement policies
You may not qualify if:
- Participation in a clinical trial with an investigational drug (within a minimum of 30 days or 5 half-lives of the investigational drug \[whichever is longer\] prior to baseline)
- Prior treatment with Upadacitinib
- Prior treatment with the same tumor necrosis factor inhibitor as the one prescribed for this study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- AbbVielead
Study Sites (53)
Gemeinschaftspraxis Innere Medizin/Rheumatologie /ID# 278584
Freiburg im Breisgau, Baden-Wurttemberg, 79098, Germany
Rheumapraxis Heidelberg /ID# 276475
Heidelberg, Baden-Wurttemberg, 69120, Germany
Rheumapraxis Haas Tübingen /ID# 275536
Tübingen, Baden-Wurttemberg, 72072, Germany
Rheumapraxis Ulm Dr. med. Nadia Rinaldi /ID# 276293
Ulm, Baden-Wurttemberg, 89073, Germany
Dr. Med. Thomas Marycz /ID# 274646
Amberg, Bavaria, 92224, Germany
Rheumapraxis Am Webereck /ID# 274412
Augsburg, Bavaria, 86157, Germany
Dr. Harmuth /ID# 273401
Marktredwitz, Bavaria, 95615, Germany
Praxiszentrum Dr. Med. Klaus Krüger Dres. Günther Kellerer Und Paul Kellerer /ID# 276138
Munich, Bavaria, 81541, Germany
Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 274587
Planegg, Bavaria, 82152, Germany
Private Practice - Dr. Dirk Wernicke /ID# 276820
Hohen Neuendorf, Brandenburg, 16540, Germany
Praxis K. Pagel /ID# 279121
Hoppegarten, Brandenburg, 15366, Germany
Rheumahaus Studien GbR /ID# 275917
Potsdam, Brandenburg, 14467, Germany
Rheumatologisch Immunologisch /ID# 275830
Templin, Brandenburg, 17268, Germany
Rheumatism Center Mittelhessen /ID# 274641
Bad Endenbach, Hesse, 35080, Germany
Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 274291
Frankfurt am Main, Hesse, 60329, Germany
Rheumapraxis Hannover-List /ID# 273735
Hanover, Lower Saxony, 30161, Germany
Praxis. F. Bigdeli-Wilshusen /ID# 273455
Hanover, Lower Saxony, 30173, Germany
Rheumatologie Kassel /ID# 275916
Kassel, Lower Saxony, 34125, Germany
Rheumapraxis An Der Hase /ID# 276949
Osnabrück, Lower Saxony, 49074, Germany
Fachpraxis für Rheumatologie und Osteologie /ID# 275359
Weyhe, Lower Saxony, 28844, Germany
Private Practice - Dr. Thilo Klopsch - Stargarder Strasse /ID# 276367
Neubrandenburg, Mecklenburg-Vorpommern, 17033, Germany
Rheumazentrum Ruhrgebiet /ID# 275518
Herne, North Rhine-Westphalia, 44649, Germany
St.Elisabeth Hospital Meerbusch /ID# 275030
Meerbusch, North Rhine-Westphalia, 40668, Germany
Rheumazentrum Ratingen /ID# 275707
Ratingen, North Rhine-Westphalia, 40882, Germany
Praxis Dr. med. Florian Beyer /ID# 274293
Kaiserslautern, Rhineland-Palatinate, 67657, Germany
Rheumapraxis am Schlossberg /ID# 272728
Homburg, Saarland, 66424, Germany
Dr. Murawski /ID# 272724
Neunkirchen, Saarland, 66538, Germany
Knappschaftsklinikum Saar /ID# 279852
Püttlingen, Saarland, 66346, Germany
Rheumapraxis Dr. Prothmann /ID# 279851
Püttlingen, Saarland, 66346, Germany
Medizinischen Versorgungszentrums Agilomed /ID# 274887
Chemnitz, Saxony, 09130, Germany
Dr. Mueller /ID# 273081
Freiberg, Saxony, 09599, Germany
Private Practice - Dr. Frank Hamann, Dr. Andreas Teich & Dr. Konrad Boche /ID# 275358
Leipzig, Saxony, 04109, Germany
Private Practice - Dr. Ilka Schwarze /ID# 276981
Leipzig, Saxony, 04129, Germany
Private Practice - Dr. Christine Baumann /ID# 275095
Plauen, Saxony, 08523, Germany
Praxis H. Fricke-Wagner /ID# 274467
Zwickau, Saxony, 08056, Germany
Rheumapraxis Dr. Liebhaber /ID# 274888
Halle, Saxony-Anhalt, 06128, Germany
Rheumatologische Facharztpraxis /ID# 272866
Magdeburg, Saxony-Anhalt, 39104, Germany
Private Practice - Dr. Jochen Walter /ID# 280069
Rendsburg, Schleswig-Holstein, 24768, Germany
Private Practice - Dr. Thomas Kupka /ID# 273631
Altenburg, Thuringia, 04600, Germany
Rheumapraxis Weimar /ID# 272740
Weimar, Thuringia, 99427, Germany
MVZ Weserbergland /ID# 276009
Bad Pyrmont, 31812, Germany
Private Practice - Dr. Silke Zinke /ID# 276366
Berlin, 13055, Germany
MVZ Herzogin Elisabeth Hospital /ID# 272725
Braunschweig, 38114, Germany
Private Practice - Dr. Sebastian Schuh /ID# 272731
Coburg, 96450, Germany
Rheumapraxis Düren /ID# 272726
Düren, 52355, Germany
Praxis Dilltal /ID# 272727
Ehringshausen, 35630, Germany
Private Practice - Dr. Daniel Bestler /ID# 272741
Erfurt, 99096, Germany
Praxis Fiene /ID# 279410
Greifswald, 17493, Germany
Private Practice - Dr. Hauke E. Heintz /ID# 278081
Hamburg, 22391, Germany
Rheumatologische Facharztpraxis /ID# 272743
Naumburg, 06618, Germany
Praxis F. Schattenberg /ID# 280322
Waren, 17192, Germany
Cellitinnen-Krankenhaus St. Josef /ID# 275926
Wuppertal, 42105, Germany
Praxis Barmen /ID# 277514
Wuppertal, 42285, Germany
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
ABBVIE INC.
AbbVie
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 27, 2024
First Posted
December 2, 2024
Study Start
November 7, 2024
Primary Completion (Estimated)
December 1, 2028
Study Completion (Estimated)
December 1, 2028
Last Updated
February 17, 2026
Record last verified: 2026-02