Characteristics and Prognostic Outcomes of Diaphragmatic Ultrasound in Myasthenia Gravis

NCT06707727 | Active Not Recruiting

• 1 other identifier: 2024-050-01
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about the characteristics and prognostic outcomes of diaphragmatic ultrasound in myasthenia gravis. The main question it aims to answer is: Does diaphragmatic ultrasound predict prognosis of myasthenia gravis in six months? Participants diagnosed as myasthenia gravis will take the diaphragm ultrasound examinations.

Conditions

Myasthaenia Gravis

Outcome Measures

Primary Outcomes (1)

• QMG changes

  6 months

Secondary Outcomes (2)

• Changes in medication type or dose

  6 months

• respiratory infection

  6 months

Study Arms (2)

myasthenia gravis

controls

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who seek treatment at the First Affiliated Hospital of Chongqing Medical University and have fluctuating skeletal muscle weakness and at least one of the following three conditions will be included: positive reaction to cholinesterase inhibitors; Serum positive antibodies against acetylcholine receptors, muscle specific kinases, or lipoprotein related proteins; Repeated electrical stimulation examination showed a decrease in wave amplitude.

You may qualify if:

• : Patients who seek treatment at the First Affiliated Hospital of Chongqing Medical University and have fluctuating skeletal muscle weakness and at least one of the following three conditions will be included: positive reaction to cholinesterase inhibitors
• : Serum positive antibodies against acetylcholine receptors, muscle specific kinases, or lipoprotein related proteins
• : Repeated electrical stimulation examination showed a decrease in wave amplitude.

You may not qualify if:

• : Patients with lung disease or heart failure, or a history of non-invasive ventilator or tracheotomy

Sponsors & Collaborators

• First Affiliated Hospital of Chongqing Medical University: lead

Study Sites (1)

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.Fei Xiao

Study Record Dates

• First Submitted: November 25, 2024
• First Posted: November 27, 2024
• Study Start: July 1, 2024
• Primary Completion: December 31, 2025
• Study Completion (Estimated): June 30, 2026
• Last Updated: November 27, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will share

Locations

CN (1)