Radon Asthma Intervention Trial
ROME
1 other identifier
interventional
180
0 countries
N/A
Brief Summary
To determine if radon mitigation can improve asthma
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable asthma
Started Jun 2026
Longer than P75 for not_applicable asthma
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 21, 2024
CompletedFirst Posted
Study publicly available on registry
November 26, 2024
CompletedStudy Start
First participant enrolled
June 1, 2026
ExpectedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2029
Study Completion
Last participant's last visit for all outcomes
April 1, 2030
February 11, 2026
February 1, 2026
3.5 years
November 21, 2024
February 8, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Asthma symptoms
Number of Days With Asthma Symptoms
past 2 weeks
Study Arms (2)
Active Radon Mitigation
ACTIVE COMPARATORActive radon mitigation system
Inactive radon mitigation system control( sham)
SHAM COMPARATORInactive radon mitigation system looks and sounds like active but doesn't reduce radon ( sham)
Interventions
standard radon mitigation system used to reduce radon in homes
inactive radon mitigation system
Eligibility Criteria
You may not qualify if:
- Not residing at the household for at least 5 days a week or family planning to move from the current home within the next twelve months, or homes with active radon mitigation systems (if home uses a HEPA filter air purifier, family must agree to disable the purifier for 28 days prior to randomization).
- Lung disease, other than asthma, that requires daily medication (inflammatory diseases, chronic lung diseases aside from asthma, congenital cardiopulmonary conditions requiring medication or surgical treatment),
- Homes with active HEPA filters will be excluded (even though the role of HEPA filters on radon and radon particles s is expected to be minimum and other exposures can be adjust for in the analysis)
- Cardiovascular disease that requires daily medication, excluding hypertension
- Taking a beta-blocker
- Currently receiving unstable level of Immunotherapy (allergy shots)
- Coordinator/PI judgment
- Inability to perform lung function testing
- Intake of abuse drugs or alcohol, have psychiatric disorders or severe mental disability that interferes with answering questions or following instructions.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Wanda Phipatanakul
Boston Children's Hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- S Jean Emans, MD Professor of Pediatrics
Study Record Dates
First Submitted
November 21, 2024
First Posted
November 26, 2024
Study Start (Estimated)
June 1, 2026
Primary Completion (Estimated)
December 1, 2029
Study Completion (Estimated)
April 1, 2030
Last Updated
February 11, 2026
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will not share